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Transcriptional regulation by cAMP in the heart

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Abstract

Stimulation of the cAMP-dependent signalling pathway by β-adrenergic catecholamines is an important physiological mechanism to increase contractile force in the heart. In addition to this, long-term β-adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an important mechanism for a cAMP-mediated control of gene expression involved e.g. in spermiogenesis and memory/learning processes. This article discusses recent data leading to the hypothesis that this mechanism also contributes to altered gene regulation in heart failure.

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  1. Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, Domagkstrasse 12, D-48129, Münster, Germany

    F.U. Müller, J. Neumann & W. Schmitz

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Müller, F., Neumann, J. & Schmitz, W. Transcriptional regulation by cAMP in the heart. Mol Cell Biochem 212, 11–17 (2000). https://doi.org/10.1023/A:1007176030884

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