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Nerve Growth Factor Inducer, 4-Methyl Catechol, Potentiates Central Sensitization Associated with Acceleration of Spinal Glutamate Release After Mustard Oil Paw Injection in Rats

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Abstract

1.In rats, injection of mustard oil (MO) into the paw caused a gradual increase in flinching of the injected paw and this algogenic behavior corresponded with an increase in the CSF-Glu level.

2.The nerve growth factor (NGF) inducer, 4-methyl catechol (4MC), enhanced the frequency of flinching and this effect was dose dependent. In addition, spinal CSF-Glu release was significantly above baseline 10 min after MO injection. In contrast, morphine (MOR) pretreatment completely blocked this behavioral and neurohumoral effect.

3.Anti-NGF paw injection attenuated the algogenic behavior and spinal Glu release otherwise observed after 4MC treatment.

4.The results demonstrated that MO-induced hyperalgesia is associated with increased CSF-Glu release and that this effect is potentiated by a NGF inducer. These data also suggest a possible involvement of NGF in the development of central sensitization after acute peripheral nociceptive stimulation.

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Authors and Affiliations

  1. Department of Anesthesiology-Resuscitology, School of Allied Health Sciences, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8554, Japan

    Toshizo Ishikawa

  2. Department of Dental Anesthesiology, Kyusyu Dental College, 2-8-6 Manazuru, Kokura-kita, Kitakyusyu, 803-8580, Japan

    Osamu Nakanishi & Hide-ichiro Kameyama

  3. Department of Pathophysiology, Yamaguchi Prefectural University, 3-2-1, Sakurabata, Yamaguchi, 753-8502, Japan

    Naohiko Funatsu

Authors
  1. Toshizo Ishikawa
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  2. Osamu Nakanishi
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  3. Naohiko Funatsu
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  4. Hide-ichiro Kameyama
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Ishikawa, T., Nakanishi, O., Funatsu, N. et al. Nerve Growth Factor Inducer, 4-Methyl Catechol, Potentiates Central Sensitization Associated with Acceleration of Spinal Glutamate Release After Mustard Oil Paw Injection in Rats. Cell Mol Neurobiol 19, 587–596 (1999). https://doi.org/10.1023/A:1006928317312

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