The International Journal of Cardiac Imaging

, Volume 13, Issue 2, pp 115–123 | Cite as

Detection of patients with restenosis after PTCA by dipyridamole-atropine-stress-echocardiography

  • Armin W. Scherhag
  • Stefan Pfleger
  • Anja B. Schreckenberger
  • Joachim Grüttner
  • Wolfram Voelker
  • Ulrich Staedt
  • Dieter L. Heene


Stress-echocardiography (SE) has been proven to be a valuable method for the diagnosis of coronary artery disease. For patients who cannot exercise, pharmacological stress-echocardiography represents an alternative method for the induction of cardiovascular stress. Few studies exist concerning the value of dipyridamole-SE for the detection of restenosis in patients after primary successful PTCA. It has been demonstrated that the addition of atropine can significantly increase the diagnostic potential of dipyridamole-SE, especially in patients with 1- or 2-vessel disease. The purpose of our study was to investigate the diagnostic value of high-dose dipyridamole-SE plus atropine (DASE) for the detection of restenosis after primary successful PTCA. We investigated 65 patients 3–6 months after PTCA before a control angiography was performed. Restenosis was defined as > 70% lumen narrowing, determined by quantitative coronary angiography. In 20/27 patients with restenosis the DASE was pathologic (sensitivity 74%), in 34/38 patients without restenosis the DASE was normal or showed no induced WMA (specificity 89%). Patients with tight restenosis (> 90%) were always correctly detected by DASE. Concerning the different vessels, restenosis of the LAD was correctly predicted by DASE in 11/12 patients, restenosis of the LCX in 6/9 patients and restenosis of the RCA in 8/11 patients. Conclusions: From our results of our study we conclude that DASE is a reliable diagnostic method for the non-invasive evaluation of patients after PTCA. DASE can identify patients with relevant restenosis after PTCA and help to select those patients who will probably benefit from further coronary interventions.

stress-echocardiography dipyridamole-echocardiography restenosis PTCA 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Armin W. Scherhag
    • 1
  • Stefan Pfleger
    • 2
  • Anja B. Schreckenberger
    • 1
  • Joachim Grüttner
    • 1
  • Wolfram Voelker
    • 2
  • Ulrich Staedt
    • 1
  • Dieter L. Heene
    • 1
  1. 1.I Medical ClinicGermany
  2. 2.II Medical Clinic Faculty for Clinical Medicine MannheimUniversity of HeidelbergMannheimGermany

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