Antimicrobial and antiviral activities of an actinomycete (Streptomyces sp.) isolated from a Brazilian tropical forest soil

  • Doralice Rodrigues Sacramento
  • Rosalie Reed Rodrigues CoelhoEmail author
  • Márcia Dutra Wigg
  • Luiz Fernando de Toledo Luna Linhares
  • Marta Gonçalves Matos dos Santos
  • Luzia Teixeira de Azevedo Soares Semêdo
  • Antonio Jorge Ribeiro da Silva


A promising producer of bioactive compounds isolated from a Brazilian tropical soil was tested for its range of antimicrobial activities. Strain 606, classified as Streptomyces sp., could not be identified up to species level, suggesting a possible new taxon. The supernatant and 10 extracts and fractions, obtained by extraction and chromatographic techniques, presented antimicrobial activity using antibiograms. The methanolic fraction was highly active against pathogenic bacteria, phytopathogenic fungi and the human pathogenic yeast Candida albicans. It also possessed high antiviral activity inhibiting the propagation of an acyclovir-resistant herpes simplex virus type 1 strain on HEp-2 cells at non-cytotoxic concentration. The strong cytotoxic effect suggests an antitumour action.

Antimicrobial activity antiviral activity bioactive compound Brazilian tropical soil Streptomyces sp. 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Doralice Rodrigues Sacramento
    • 1
  • Rosalie Reed Rodrigues Coelho
    • 1
    Email author
  • Márcia Dutra Wigg
    • 1
  • Luiz Fernando de Toledo Luna Linhares
    • 1
  • Marta Gonçalves Matos dos Santos
    • 1
  • Luzia Teixeira de Azevedo Soares Semêdo
    • 1
  • Antonio Jorge Ribeiro da Silva
    • 2
  1. 1.Instituto de Microbiologia Prof. Paulo de GóesUniversidade Federal do Rio de JaneiroRio de Janeiro, RJBrazil
  2. 2.Núcleo de Pesquisas de Produtos NaturaisUniversidade Federal do Rio de JaneiroRio de Janeiro, RJBrazil

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