Veterinary Research Communications

, Volume 29, Issue 4, pp 281–286 | Cite as

Qualitative Risk Assessment of Chronic Renal Failure Development in Healthy, Female Cats as Based on the Content of Eicosapentaenoic Acid in Adipose Tissue and That of Arachidonic Acid in Plasma Cholesteryl Esters

  • E.A. Plantinga
  • R. Hovenier
  • A.C. Beynen


A study was carried out to assess the qualitative risk of development of chronic renal failure (CRF) in young healthy, female cats as based on the content of arachidonic acid (AA) in plasma cholesteryl esters (CE) and eicosapentaenoic acid (EPA) in adipose tissue. It has been suggested that the content of AA in CE should be <10% of total fatty acids (TFA) and of EPA in adipose tissue be >1.4% of TFA. Subcutaneous adipose tissue and blood samples were obtained from 48 female cats. There was a statistically significant correlation between linoleic acid content of adipose tissue and that of plasma CE. In all cats the EPA content of adipose tissue was lower than 1.4% of TFA and in 30 cats that of AA in plasma CE was higher than 10% of TFA. The EPA content of adipose tissue and the AA content of plasma CE are determined by the contents of these fatty acids in the diet. It is concluded that the fatty acid composition of cat foods should be determined and that, if deemed necessary, the ingredient composition should be altered so that the content of EPA is raised and that of AA is lowererd.

chronic renal failure cats adipose tissue plasma cholesteryl esters arachidonic acid eicosapentaenoic acid 


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  1. Beaton, G.H., Milner, J., Corey, P., McGuire, V., Cousins, M., Steward, E., De Ramos, M., Hewitt, D., Grambsch, P.Y., Kassim, N. and Little J.A., 1979. Sources of variance in 24-hour dietary recall data: implications for nutritionstudy design and interpretation. American Journal of Clinical Nutrition, 32, 2546Google Scholar
  2. Beynen, A.C., Hermus, R.I and Hautvast, J.G.A.G., 1980. A mathematical relationship between the fatty acid composition of the diet and that of the adipose tissue in man. American Journal of Clinical Nutrition, 33, 81-85Google Scholar
  3. Brown, S.A., Brown, C.A., Crowell, W.A., Barsanti, J.A. and Finco, D.R., 1996. Does modifying dietary lipids influence the progression of renal failure? Veterinary Clinics of North America. Small Animal Practice, 26, 1277Google Scholar
  4. Elliott, I, Rawlings, J.M., Markwell, P.J. and Barber, P.J., 2000. Survival of cats with naturally occurring chronic renal failure: effect of conventional dietary management. Journal of Small Animal Practice, 41 , 235Google Scholar
  5. Hamilton, J.G. and Comai, K., 1988. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids, 23, 1146Google Scholar
  6. Jonas, A., 1986. Synthetic substrates of lecithin:cholesterol acyltransferase. Journal of Lipid Research, 27, 689Google Scholar
  7. Liu, M., Bagdade, J.D. and Subbaiah P.Y., 1995. Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species. Journal of Lipid Research, 36, 1813Google Scholar
  8. Krall, E.A., Dwyer, J.T. and Coleman, K.A., 1988. Factors influencing accuracy of dietary recall. Nutrition Research, 8, 829-41Google Scholar
  9. Metcalfe, L.D., Schmitz, A.A. and Pekka, J.R., 1966. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Analytical Chemistry, 18, 514Google Scholar
  10. Plakké, T., Berkel, J., Beynen, A.C., Hermus, R.J.J. and Katan, M.B., 1983. Relationship between the fatty acid composition of the diet and that of the subcutaneous adipose tissue in individual human subjects. Human Nutrition: Applied Nutrition, 37A, 365-372Google Scholar
  11. Plantinga, E.A. and Beynen, A.C., 2003a. A case-control study on the intake of polyunsaturated fatty acids and chronic renal failure in cats. Journal of Applied Research in Veterinary Medicine, 1, 127-132Google Scholar
  12. Plantinga, E.A. and Beynen, A.C., 2003b. The influence of dietary polyunsaturated fatty acid supplementation on the composition of plasma cholesterylesters in healthy adult cats. Journal of Animal Physiology and Animal Nutrition, 87, 373-379Google Scholar
  13. Plantinga, E.A. and Beynen, A.C., 2004. Evaluatie van commerciele nierdieten voor katten, met bijzondere aandacht voor de vetzuursamenstelling. Tijdschrift voor Diergeneeskunde (in press)Google Scholar
  14. Plantinga, E.A., Van Dijk, N., Van Niel, M.H.F. and Beynen, A.C., 2003. Relationship between the amount oflinoleic acid in the diet and that in adipose tissue of adult cats living freely in households. Veterinary Research Communications, 27, 603-610Google Scholar
  15. Van Niel, M.H.F. and Beynen, A.C., 1997. The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. The Veterinary Quarterly, 19, 150-153Google Scholar
  16. Van Staveren, W.A., Burema, J., Deurenberg, P. and Katan, M.B., 1988. Weak associations in nutritional epidemiology: the importance of replication of observations on individuals. International Journal of Epidemiology, 17, 964-969Google Scholar
  17. Wang, S.T. and Peter, F., 1983. Gas-liquid chromatographic determination of fatty acid composition of cholesteryl esters in human serum using silica Sep-Pak cartridges. Journal of Chromatography, 276, 249Google Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • E.A. Plantinga
    • 1
  • R. Hovenier
    • 1
  • A.C. Beynen
    • 1
  1. 1.Department of Nutrition, Faculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands

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