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Veterinary Research Communications

, Volume 28, Issue 7, pp 609–616 | Cite as

Clinical and Pathological Aspects of Experimental Oleander (Nerium oleander) Toxicosis in Sheep

  • M.R. Aslani
  • A.R. Movassaghi
  • M. Mohri
  • A. Abbasian
  • M. Zarehpour
Article

Abstract

Dried Nerium oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to six native male sheep. Clinical signs of toxicosis in sheep began to appear about 30 min after receiving the oleander and included decrease of the heart rate followed by cardiac pauses and tachyarrhythmias; ruminal atony, mild to moderate tympany, abdominal pain, polyuria and polakiuria. Electrocardiography revealed bradycardia, atrio-ventricular blocks, depression of S-T segments, ventricular premature beats and tachycardia, and ventricular fibrillation. Five sheep died within 4–12 h and one survived. At necropsy there were varying degrees of haemorrhages in different organs and gastroenteritis. Histopathological examination of tissue sections revealed myocardial degeneration and necrosis, degeneration and focal necrosis of hepatocytes, necrosis of tubular epithelium in kidneys, oedema in the lungs, and ischemic changes in the cerebrum.

cardiac glycosides Nerium oleander sheep toxicosis 

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REFERENCES

  1. Adams, H.R., 1995. Digitalis and vasodilator drugs. In: H.R. Adams (ed.), Veterinary Pharmacology and Therapeutics, 7th edn., (Iowa State University Press, Ames, IA), 455–463Google Scholar
  2. Arai, M., Stauber, E. and Shropshire, C.M., 1992. Evaluation of selected plants for their toxic effects in canaries. Journal of American Veterinary Medical Association, 200, 1329–1331Google Scholar
  3. Aslani, M.R., 1995. Study on the mechanism of V285 in treatment of experimental oleander poisoning in calves, (DVSc thesis, University of Shiraz, Iran)Google Scholar
  4. Aslani, M.R. and Rezakhani, A., 2000. A case report of oleander (Nerium oleander) intoxication in cattle. International Journal of Tropical Agriculture, 18, 185–187Google Scholar
  5. Burton, L.E., Picchioni, A.L. and Chin, L., 1965. Dipotassium editate as an antidote in poisoning from oleander and its chief glycoside, oleandrin. Archive of International Pharmacodynamics, 158, 202–211Google Scholar
  6. Casteel, S.W. and Turk, J.R., 2002. Collapse and sudden death. In: B.P. Smith (ed.), Large Animal Internal Medicine, 3rd edn., (Mosby, St. Louis, MO), 251–252Google Scholar
  7. Fowler, M.E., 1993. Cardiotoxic plants. In: J.L. Howard (ed.), Current Veterinary Therapy 3, Food Animal Practice, (W.B. Saunders, Philadelphia), 89–90Google Scholar
  8. Frohn, D. and Pfander, H. J., 1983. A Colour Atlas of Poisonous Plants, (Wolf Science, London)Google Scholar
  9. Galey, F.D., Holstege, D.M., Plumlee, K.H., Tor, E., Johnson, B., Anderson, M.L., Blanchard, P.C. and Brown, F., 1996. Diagnosis of oleander poisoning in livestock. Journal of Veterinary Diagnosis Investigation, 8, 358–364Google Scholar
  10. Galey, F.D., 1999. Oleander (Nerium oleander) toxicosis. In: J.L. Howard (ed.), Current Veterinary Therapy 4, Food Animal Practice, (W.B. Saunders, Philadelphia), 275–276Google Scholar
  11. Henning, M.W., 1932. Animal Diseases in South Africa, vol II, Virus and Deficiency Diseases, Plant Poisons, (Gengra News Agency, South Africa)Google Scholar
  12. Humphreys, D. J., 1988. Veterinary Toxicology, (Baillière-Tindall, London)Google Scholar
  13. Joubert, J.P.J., 1989. Cardiac glycosides. In: P.R. Cheeke (ed.), Toxicants of Plant Origin, vol II, Glycosides, (CRC Press, Florida), 72Google Scholar
  14. Katzung, B.G., and Parmley, W.W., 1998. Cardiac glycosides and other drugs used in congestive heart failure. In: B.G. Katzung (ed.), Basic and Clinical Pharmacology, (Librairie du Liban, Beirut)Google Scholar
  15. Kellerman, T.S., Coetzer, J.A.W. and Naude, T.W., 1989. Poisonous Plants and Mycotoxicoses of Livestock in Southern Africa, (Oxford University Press, Cape Town), 84–85Google Scholar
  16. Longford, S.D. and Boor, P.J., 1996. Oleander toxicity: an examination of human and animal toxic exposure. Toxicology, 109, 1–13CrossRefGoogle Scholar
  17. Oryan, A., Maham, M., Rezakhani, A. and Maleki, M., 1996. Morphological studies on experimental oleander poisoning in cattle. Journal of Veterinary Medicine series A, 43, 625–634PubMedCrossRefGoogle Scholar
  18. Panwar, H.S. and Garg, K.G., 2000. Nerium oleander. In: S.K. Garg (ed.), Veterinary Toxicology, (CBS Publishers, New Delhi), 104–106Google Scholar
  19. Radostits, O.M., Gay, C.C., Blood, D.C. and Hinchcliff, K.W., 2000. Veterinary Medicine, 9th edn., (W.B. Saunders, London)Google Scholar
  20. Rezakhani, A. and Maham, M., 1994. Cardiac manifestation of oleander poisoning in cattle and donkeys. In: S.M. Colegate and P.R. Darling (eds), Plant Associated Toxins - Agricultural, Phytochemical and Ecological Aspects, (CAB International, London)Google Scholar
  21. Schwarts, W.L., Bay, W.W., Dollahitte, J.W., Storts, R.W. and Russel, L.H., 1974. Toxicity of Nerium oleander in the monkey (Cebus apella). Veterinary Pathology, 11, 259–277CrossRefGoogle Scholar
  22. Shaw, D.E. and Pearn, J., 1979. Oleander poisoning. Medical Journal of Australia, 2, 267–269PubMedGoogle Scholar
  23. Shropshire, C.M., Stauber, E. and Arai, M., 1992. Evaluation of selected plants for acute toxicosis in budgerigars. Journal of the American Veterinary Medical Association, 200, 936–939PubMedGoogle Scholar
  24. Szabuniewicz, M., McCardy, W.L. and Camp, B.J., 1971. Treatment of experimentally induced oleander poisoning. Archives Internationales de Pharmacodynamie, 189, 12–21Google Scholar
  25. Szabuniewicz, M., Schwarts, W.L., McCardy, W.L., Russel, L.H. and Camp, B.J., 1972. Experimental oleander poisoning and treatment. South-Western Veterinarian, 25, 105–114Google Scholar
  26. Vashishta, M.S. and Singh, R.P., 1977. Camel Diseases in India, (Scientific Book Agency, Calcutta)Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • M.R. Aslani
    • 1
  • A.R. Movassaghi
    • 2
  • M. Mohri
    • 1
  • A. Abbasian
    • 1
  • M. Zarehpour
    • 2
  1. 1.Department of Clinical Sciences, School of Veterinary MedicineFerdowsi University of MashhadMashhadIran
  2. 2.Department of Pathobiology, School of Veterinary MedicineFerdowsi University of MashhadMashhadIran

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