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Structural Chemistry

, Volume 15, Issue 3, pp 215–221 | Cite as

Structural Studies by NMR and X-Ray Crystallography of N-(p-Toluenesulfonyl)-Amino Acids

  • Liliana Aguilar-Castro
  • Margarita Tlahuextl
  • Antonio R. Tapia-BenavidesEmail author
  • José Guadalupe Alvarado-Rodríguez
Article

Abstract

N-(p-Toluenesulfonyl)-glycine 7 and analogous derivatives of d,l-alanine 8, L-valine 9, L-leucine 10, L-isoleucine 11, and L-phenylalanine 12 were synthesized by condensation of the amino acid with p-toluenesulfonyl chloride. The presence of intermolecular hydrogen bonding was established by variable NMR spectroscopy. The molecular structure and intermolecular interactions of N-(p-toluenesulfonyl)–d,l-alanine and N-(p-toluenesulfonyl)–L-valine were corroborated by X-ray diffraction (XRD) experiments.

Hydrogen bonding sulfonylamides amino acids VT-NMR 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Liliana Aguilar-Castro
    • 1
  • Margarita Tlahuextl
    • 1
  • Antonio R. Tapia-Benavides
    • 1
    Email author
  • José Guadalupe Alvarado-Rodríguez
    • 1
  1. 1.Centro de Investigaciones QuímicasUniversidad A. del Estado de HidalgoPachucaMéxico

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