Somatic Cell and Molecular Genetics

, Volume 25, Issue 1, pp 33–39 | Cite as

The Human RNA Helicase A (DDX9) Gene Maps to the Prostate Cancer Susceptibility Locus at Chromosome Band 1q25 and Its Pseudogene (DDX9P) to 13q22, Respectively

  • Chee-Gun Lee
  • Toshihiko Eki
  • Katsuzumi Okumura
  • Masahiro Nogami
  • Vera da Costa Soares
  • Yasufumi Murakami
  • Fumio Hanaoka
  • Jerard Hurwitz
Article

Abstract

RNA helicase A is the homolog of the Drosophila maleless protein, an essential factor involved in dosage compensation, and plays a crucial role in early development in mammals. Here, we have mapped the human RNA helicase A (DDX9) gene to the major susceptibility locus for prostate cancer at chromosome band 1q25, and its pseudogene (DDX9P) to the band 13q22 by fluorescence in situ hybridization, somatic cell hybrid analysis, and assignment of YAC clones, respectively.

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LITERATURE CITED

  1. 1.
    Lee, C.G., and Hurwitz, J. (1992). J. Biol. Chem. 267:4398–4407.Google Scholar
  2. 2.
    Fukunaga, A., Tanaka, A., and Oishi, K. (1975). Genetics 81:135–141.Google Scholar
  3. 3.
    Kuroda, M.I., Kernan, M.J., Kreber, R., Ganetzky, B., and Baker, B.S. (1991). Cell 66:935–947.Google Scholar
  4. 4.
    Lee, C.G., and Hurwitz, J. (1993). J. Biol. Chem. 268:16822–16830.Google Scholar
  5. 5.
    Zhang, S., Macke, H., and Grosse, F. (1995). J. Biol. Chem. 270:16422–16427.Google Scholar
  6. 6.
    Lee, C.G., Chang, K.A., Kuroda, M.I., and Hurwitz, J. (1997). EMBO J. 16:2671–2681.Google Scholar
  7. 7.
    Nakajima, T., Uchida, C., Anderson, S.F., Lee, C.G., Hurwitz, J., Parvin, J.D., and Montminy, M. (1997). Cell 90:1107–1112.Google Scholar
  8. 8.
    Lee, C.G., da Costa Soares, V., Newberger, C., Manova, K., Lacy, E., and Hurwitz, J. (1998). Proc. Natl. Acad. Sci. U.S.A. 95:13709–13713.Google Scholar
  9. 9.
    Lee, C.G., Eki, T., Okumura, K., Soares, V., and Hurwitz, J. (1998). Genomics 47:365–371.Google Scholar
  10. 10.
    Okumura, K., Nogami, M., Taguchi, H., Dean, F.B., Chen, M., Pan, Z.Q., Hurwitz, J., Shiratori, A., Murakami, Y., Ozawa, K., and Eki, T. (1995). Genomics 25:274–278.Google Scholar
  11. 11.
    Dubois, B.L., and Naylor, S.L. (1993). Genomics 16: 315–319.Google Scholar
  12. 12.
    Chumakov, I., Rigault, P., Le Gall, I., et al. (1995). Nature 377:175–297.Google Scholar
  13. 13.
    Takahashi, E., Hori, T., O'Conell, P., Leppert, M., and White, P. (1990). Hum. Genet. 86:14–16.Google Scholar
  14. 14.
    Lichter, P., Cremer, T., Borden, J., Manuelidis, L., and Ward, D.C. (1988). Hum. Genet. 80:224–234.Google Scholar
  15. 15.
    Takahashi, E., Yamauchi, M., Tsuji, H., Hitomi, A., Meuth, M., and Hori, T. (1991). Hum. Genet. 88:119–121.Google Scholar
  16. 16.
    Maniatis, T., Fritsch, E.F., and Sambrook, J. (1989). Molecular cloning: a laboratory manual, 2nd edition. CSH Laboratory Press, Cold Spring Harbor, NY.Google Scholar
  17. 17.
    Banfi, S., Borsani, G., Rossi, E., Bernard, L., Guffanti, A., Rubboli, F., Marchitiello, A., Giglio, S., Coluccia, E., Zollo, M., Zuffardi, O., and Ballabio, A. (1996). Nature Genet. 13:167–174.Google Scholar
  18. 18.
    Klockars, T., Isosomppi, J., Laan, M., Kakko, N., Palotie, A., and Peltonen, L. (1997). Genomics 44: 355–357.Google Scholar
  19. 19.
    DeBry, R.W., and Seldin, M.F. (1996). Genomics 33:337–351.Google Scholar
  20. 20.
    Smith, J.R., Freije, D., Carpten, J.D., Gronberg, H., Xu, J., Isaacs, S.D., Brownstein, M.J., Bova, G.S., Guo, H., Bujnovszky, P., Nusskern, D.R., Damber, J.E., Bergh, A., Emanuelsson, M., Kallioniemi, O.P., Walker-Daniels, J., Bailey-Wilson, J.E., Beaty, T.H., Meyers, D.A., Walsh, P.C., Collins, F.S., Trent, J.M., and Isaacs, W.B. (1996). Science 274:1371–1374.Google Scholar
  21. 21.
    Cooney, K.A., McCarthy, J.D., Lange, E., Huang, L., Miesfeldt, S., Montie, J.E., Oesterling, J.E., Sandler, H.M., and Lange, K. (1997). J. Natl. Cancer Inst. 89:955–959.Google Scholar
  22. 22.
    McIndoe, R.A., Stanford, J.L., Gibbs, M., Jarvik, G.P., Brandzel, S., Neal, C.L., Li, S., Gammack, J.T., Gay, A.A., Goode, E.L., Hood, L., and Ostrander, E.A. (1997). Am. J. Hum. Genet. 61:347–353.Google Scholar
  23. 23.
    Noto, S., Maeda, T., Hattori, S., Inazawa, J., Imamura, M., Asaka, M., and Hatakeyama, M. (1998). FEBS Lett. 441:127–131.Google Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Chee-Gun Lee
    • 1
  • Toshihiko Eki
    • 2
  • Katsuzumi Okumura
    • 3
  • Masahiro Nogami
    • 3
  • Vera da Costa Soares
    • 1
  • Yasufumi Murakami
    • 2
  • Fumio Hanaoka
    • 2
  • Jerard Hurwitz
    • 1
  1. 1.Graduate Program in Molecular BiologyMemorial Sloan-Kettering Cancer CenterNew York
  2. 2.Cellular Physiology LaboratoryThe Institute of Physical and Chemical Research (RIKEN)SaitamaJapan
  3. 3.Faculty of BioresourcesMie University, TsuMieJapan

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