Russian Journal of Genetics

, Volume 40, Issue 7, pp 795–799 | Cite as

Mitochondrial DNA Variation in Two Russian Populations from Novgorod Oblast

  • A. V. Lunkina
  • G. A. Denisova
  • M. V. Derenko
  • B. A. Malyarchuk
Article

Abstract

Mitochondrial DNA (mtDNA) polymorphism was examined in two Russian populations of Novgorod oblast, from the city of Velikii Novgorod (n = 81), and the settlement of Volot (n = 79). This analysis showed that the mitochondrial gene pool of Russians examined was represented by the mtDNA types belonging to 20 haplogroups and subhaplogroups distributed predominantly among the European populations. Haplogroups typical of the indigenous populations of Asia were found in the population sample from Velikii Novgorod with the average frequency of 3.7% (haplogroups A, Z, and D5), and with the frequency of 6.3% (haplogroups Z, D, and M*) in the Volot population. It was demonstrated that the frequency of the mitochondrial lineages combination, D5, Z, U5b-16144, and U8, typical of the Finnish-speaking populations of Northeastern Europe, was somewhat higher in the urban population (7.4%) compared to rural one (3.8%). The problem of genetic differentiation of Russians from Eastern Europe inferred from mtDNA data, is discussed.

Keywords

Genetic Differentiation Population Sample Gene Pool Urban Population European Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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REFERENCES

  1. 1.
    Alekseev, V.P.,Proiskhozhdenie narodov VostochnoiEvropy (kraniologicheskoeissledovanie) (The Origin of East European Ethnic Groups (A Craniological Study)),Moscow: Nauka, 1969.Google Scholar
  2. 2.
    Alekseeva, T.I., Etnogenez vostochnykh slavyan (Ethnogenesis of Eastern Slavs), Moscow: Mosk. Gos. Univ., 1973.Google Scholar
  3. 3.
    Sedov, V.V., Vostochnye slavyane v VI-XIII vv. (Eastern Slavs in the 6th to 13th Centuries), Moscow: Nauka, 1982.Google Scholar
  4. 4.
    Alekseeva, T.I., The Anthropological Type of Russians, in Voprosy antropologii, dialektologii i etnografii russkogo naroda (Problems of Anthropology, Dialectology, and Ethnography of the Russian People), Moscow: Inst. Etnol. Antropol., 1998, pp. 3–27.Google Scholar
  5. 5.
    Rychkov, Yu.G. and Balanovskaya, E.V., Generalized Cartographic Analysis in Anthropology: A Reflection of Chronicle Slavonic Tribes in Anthropological Geography of the Modern Russian Population, Vopr. Antropol., 1988, no. 80, pp. 3–37.Google Scholar
  6. 6.
    Spitsyn, V.A., Kuchheuser, W., Makarov, S.V., et al., The Russian Gene Pool: Frequencies of Genetic Markers, Genetika (Moscow), 2001, vol. 37, no. 3, pp. 386–401.PubMedGoogle Scholar
  7. 7.
    Shneider, Yu.V., Shil'nikova, I.N., and Zhukova, O.V., Material for Studying the Gene Pools of Russia and Neighboring Countries: The Russian Population of the Pskov Oblast, Genetika (Moscow), 2002, vol. 38, no. 11, pp. 1561–1565.PubMedGoogle Scholar
  8. 8.
    Balanovskaya, E.V., Balanovsky, O.P., Spitsyn, V.A., et al., The Russian Gene Pool: Gene Geography of Erythrocytic Gene Markers (ACP1, PGM1, ESD, GLO1, and 6-PGD), Genetika (Moscow), 2001, vol. 37, no. 8, pp. 1138–1151.PubMedGoogle Scholar
  9. 9.
    Malyarchuk, B.A., Denisova, G.A., Derenko, M.V., et al., Mitochondrial DNA Variation in Russian Populations of Krasnodar Krai, Belgorod, and Nizhni Novgorod Oblasts, Genetika (Moscow), 2001, vol. 37, no. 10, pp. 1411–1416.PubMedGoogle Scholar
  10. 10.
    Malyarchuk, B.A., Derenko, M.V., Grzybowski, T., et al., Mitochondrial DNA Variation in Russian Populations of Stavropol Krai, Orel and Saratov Oblasts, Genetika (Moscow), 2002, vol. 38, no. 11, pp. 1532–1538.PubMedGoogle Scholar
  11. 11.
    Malyarchuk, B.A., Grzybowski, T., Derenko, M.V., et al., Mitochondrial DNA Variability in Poles and Russians, Ann. Hum. Genet., 2002, vol. 66, pp. 261–283.CrossRefPubMedGoogle Scholar
  12. 12.
    Macaulay, V., Richards, M., Hickey, E., et al., The Emerging Tree of West Eurasian mtDNAs: A Synthesis of Control-Region Sequences and RFLPs, Am. J. Hum. Genet., 1999, vol. 64, pp. 232–249.CrossRefPubMedGoogle Scholar
  13. 13.
    Richards, M., Macaulay, V., Hickey, E., et al., Tracing European Founder Lineages in the Near Eastern mtDNA Pool,Am. J. Hum. Genet., 2000, vol. 67, pp. 1251–1276.PubMedGoogle Scholar
  14. 14.
    Anderson, S., Bankier, A.T., Barrel, B.G., et al., Sequence and Organization of the Human Mitochondrial Genome, Nature,1981, vol. 290, pp.457–465.PubMedGoogle Scholar
  15. 15.
    Torroni, A., Huoponen, K., Francalacci, P., et al., Classi-fication of European mtDNAs from an Analysis of Three European Populations, Genetics, 1996, vol. 144, pp. 1835–1850.PubMedGoogle Scholar
  16. 16.
    Finnila, S., Hassinen, I., Ala-Kokko, L., and Majamaa, K., Phylogenetic Network of the mtDNA Haplogroup U in Northern Finland Based on Sequence Analysis of the Complete Coding Region by Conformation-Sensitive Gel Electrophoresis, Am. J. Hum. Genet., 2000, vol. 66, pp. 1017–1026.CrossRefPubMedGoogle Scholar
  17. 17.
    Yao, Y.-G., Kong, Q.-P., Bandelt, H.-J., et al., Phylogenetic Differentiation of Mitochondrial DNA in Han Chinese, Am. J. Hum. Genet., 2002, vol. 70, pp.635–651.CrossRefPubMedGoogle Scholar
  18. 18.
    Malyarchuk, B.A., Rogozin, I.B., Berikov, V.B., and Derenko, M.V., Analysis of Phylogenetically Reconstructed Mutational Spectra in Human Mitochondrial DNA Control Region, Hum. Genet., 2002, vol. 111, pp. 46–53.CrossRefPubMedGoogle Scholar
  19. 19.
    Finnila, S., Lehtonen, M.S., and Majamaa, K., Phylogenetic Network for European mtDNA,Am. J. Hum.Genet., 2001, vol. 68, pp. 1475–1484.CrossRefPubMedGoogle Scholar
  20. 20.
    Rousset, F. and Raymond, M., Testing Heterozygote Excess and Deficiency, Genetics, 1995, vol. 140, pp. 1413–1419.PubMedGoogle Scholar
  21. 21.
    Schneider, S., Roessli, D., and Excoffier, L., Arlequin Ver. 2.000: A Software for Population Genetics Data Analysis , Geneva: Univ. of Geneva, 2000.Google Scholar
  22. 22.
    Orekhov, V., Poltoraus, A., Zhivotovsky, L.A., et al., Mitochondrial DNA Sequence Diversity in Russians, FEBS Lett., 1999, vol. 445, pp. 197–201.CrossRefPubMedGoogle Scholar
  23. 23.
    Malyarchuk, B.A., Variation of the Human Mitochondrial Genome and the Genetic History of Slavs, Doctoral (Biol.) Dissertation , Moscow: Vavilov Inst. General Genet., 2003.Google Scholar
  24. 24.
    Tambets, K., Kivisild, T., Metspalu, E., et al., The Topology of the Maternal Lineages of the Anatolian and Trans-Caucasus Populations and the Peopling of Europe: Some Preliminary Considerations,Archaeogenetics: DNA and the Population Prehistory of Europe,Renfrew, C. and Boyle, K., Eds., Cambridge: McDonald Inst. for Archaeol. Res., 2000, pp. 219–235.Google Scholar
  25. 25.
    Meinila, M., Finnila, S., and Majamaa, K., Evidence for mtDNA Admixture between the Finns and the Saami, Hum. Hered., 2000, vol. 52, pp. 160–170.Google Scholar
  26. 26.
    Bermisheva, M., Tambets, K., Villems, R., and Khusnutdinova, E., Diversity of Mitochondrial DNA Haplogroups in Ethnic Populations of the Volga-Ural Region, Mol. Biol. (Moscow), 2002, vol. 36, no. 6, pp. 990–1001.Google Scholar
  27. 27.
    Sajantila, A., Lahermo, P., Anttinen, T., et al., Genes and Languages in Europe-An Analysis of Mitochondrial Lineages, Genome Res., 1995, vol. 5, pp. 42–52.PubMedGoogle Scholar
  28. 28.
    Kasperavičiute, D. and Kucinskas, V., Variability of the Human Mitochondrial DNA Control Region Sequences in the Lithuanian Population, J. Appl. Genet., 2002, vol. 43, pp. 255–260.Google Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2004

Authors and Affiliations

  • A. V. Lunkina
    • 1
  • G. A. Denisova
    • 1
  • M. V. Derenko
    • 1
  • B. A. Malyarchuk
    • 1
  1. 1.Institute of Biological Problems of the NorthRussian Academy of SciencesMagadanRussia

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