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Russian Journal of Bioorganic Chemistry

, Volume 30, Issue 6, pp 523–533 | Cite as

Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells

  • M. V. Sidorova
  • A. S. Molokoedov
  • T. I. Aref'eva
  • N. B. Kukhtina
  • T. L. Krasnikova
  • Zh. D. Bespalova
  • V. N. Bushuev
Article

Abstract

Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time.

chemokine MPC-1 monocytes MCP-1-induced migration solid phase peptide synthesis synthetic peptides 

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Copyright information

© MAIK “Nauka/Interperiodica” 2004

Authors and Affiliations

  • M. V. Sidorova
    • 1
  • A. S. Molokoedov
    • 1
  • T. I. Aref'eva
    • 1
  • N. B. Kukhtina
    • 1
  • T. L. Krasnikova
    • 1
  • Zh. D. Bespalova
    • 1
  • V. N. Bushuev
    • 1
  1. 1.Cardiological Research and Production AssociationMinistry of Health of the Russian FederationMoscowRussia

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