Quality of Life Research

, Volume 13, Issue 8, pp 1369–1379 | Cite as

Determinants of Health-Related Quality of Life in Long-Term Survivors of Hodgkin's Lymphoma

  • L. Wettergren
  • M. Björkholm
  • U. Axdorph
  • A. Langius-Eklöf


In this study health-related quality of life (HRQL) in long-term survivors of Hodgkin's lymphoma (HL) was evaluated and the findings were analyzed using a conceptual model developed by Wilson and Cleary. A better understanding of the relationships between the variables explaining HRQL may improve care and rehabilitation of HL patients. The populations were long-term survivors of HL (n=121) and a control group (n = 236). Participants were approached with one semi-structured interview, an extended version of the Schedule for the Evaluation of Individual Quality of Life – Direct Weighting (SEIQoL-DW) and three standardized questionnaires: Hospital Anxiety and Depression (HAD) scale, Short Form 12 health survey questionnaire (SF-12) and Sense of Coherence (SOC) scale. No differences regarding the mean scores were found between the HL survivors and the controls except for the SF-12, where the patients considered themselves to be in poorer physical health than the controls (p < 0.01). Even though physical health was diminished, patients did not evaluate overall QoL worse compared to the controls. The major determinants of perception of general QoL were self-rated physical and mental health as well as SOC. The HRQL of persons who have survived a median of 14years with HL is similar to that of controls.

Conceptual model Health-related quality of life Hodgkin's lymphoma Individual quality of life SEIQoL-DW 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • L. Wettergren
    • 1
  • M. Björkholm
    • 2
  • U. Axdorph
    • 2
  • A. Langius-Eklöf
    • 1
  1. 1.Division of Nursing Research, Department of NursingKarolinska Institutet; Division of Hematology, Department of Medicine, Karolinska HospitalStockholmSweden (E-mail:
  2. 2.Division of Hematology, Department of MedicineKarolinska HospitalStockholmSweden

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