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Quality of Life Research

, Volume 13, Issue 2, pp 481–488 | Cite as

Radiation related morbidities and their impact on quality of life in head and neck cancer patients receiving radical radiotherapy

  • M. Bansal
  • B.K. Mohanti
  • N. Shah
  • R. Chaudhry
  • S. Bahadur
  • N.K. Shukla
Article

Abstract

Although 50–70% of head and neck cancer patients in India receive radiotherapy (RT), radiation-related acute and late morbidities and their impact on quality of life (QOL) are infrequently reported. Acute and late radiation morbidities and QOL were assessed in a prospective longitudinal study of 45 patients with head and neck cancers receiving radical RT to a dose of 7000 cGy in conventional fractionation. Grade II acute morbidities experienced by the largest percent of the sample during the course of RT pertained to the mucosa (66.4%), salivary gland (84%), and oesophagus (53%). These morbidities led to an increase in the symptom scores of appetite loss (76.46), fatigue (65.75) and pain (44.77). This increase in the symptom scores consequently led to a significant decline in physical, social and emotional functioning as well as global health status score during the course of RT (p < 0.001). Scores improved after 1 month of RT but did not reach the pre-RT value. Future studies may consider correlating QOL assessment to significant patient and disease related parameters such as performance status, weight loss, stage and site of disease.

Head and neck cancers Quality of life Radiation morbidities 

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References

  1. 1.
    Gotay CC. Trial related quality of life; using quality of life instrument to distinguish among cancer therapies. Monograph J Natl Cancer Inst 1996; 20: 1-6Google Scholar
  2. 2.
    Bjordal K, Kaasa S, Mastekaasa A. Quality of life in patients treated for head and neck cancer. A follow-up study 7 to 11 year after radiotherapy. Int J Radiat Oncol Biol Phys 1994: 28: 847-856.Google Scholar
  3. 3.
    Chawla S, Mohanti BK, Rakshak M, Saxena S, Rath GK, Bahadur S. Temporal assessment of quality of life of head and neck cancer patients receiving radical radiotherapy. Qual Life Res 1999; 8: 73-78.Google Scholar
  4. 4.
    Finizia C, Hammerlid E, Westin T, Lindstrom J. Quality of life and voice in patients with laryngeal carcinoma. A posttreatment comparison of laryngectomy (salvage surgery) versus radiotherapy. Laryngoscope 1998; 108: 1566-1573.Google Scholar
  5. 5.
    National Cancer Registry Programme, Biennial Report, 1988–89: An epidemiological study. Indian Council of Medical Research, New Delhi, 1992.Google Scholar
  6. 6.
    Consensus Conference. Oral complications of cancer therapies: Diagnosis, prevention and treatment. National Institutes of Health Conn Med 1989; 53: 595-601.Google Scholar
  7. 7.
    Epstein JB, Emerton S, Kolbinson DA, Le ND, Phillips N. Stevenson-Moore D. Quality of life and oral function following radiotherapy for head and neck cancer. Head Neck 1999; 21: 1-11.Google Scholar
  8. 8.
    Ringash J, Redelmeier DA, O'Sullivan B, Bezjak A. Quality of life and utility in irradiated laryngeal cancer patients. Int J Radiat Oncol Biol Phys 2000; 47: 875-881.Google Scholar
  9. 9.
    Schwartz S, Patrick DL, Yueh B. Quality of life outcomes in the evaluation of head and neck cancer treatments. Arch Otolaryngol HN Surg 2001; 127: 673-678.Google Scholar
  10. 10.
    Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organisation for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-1346.Google Scholar
  11. 11.
    Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH. Late effects of normal tissues. Consensus conference. Int J Radiat Oncol Biol Phys 1995; 31: 1035-1365.Google Scholar
  12. 12.
    Aaronson NK, Ahmedzai S, Bergman B, et al. EORTC QLQ-C30. A quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365-376.Google Scholar
  13. 13.
    Bjordal K, Kaasa S. Psychometric validation of the EORTC core QOL Questionnaire, 30-item version and a diagnosis specific module for head and neck cancer patient. Acta Oncol 1992; 31: 311-321.Google Scholar
  14. 14.
    Kaasa S, Bjordal K, Aaronson NK, et al. The EORTC core QOL questionnaire (QLQ-C30). Validity and reliability when analysed with patients treated with palliative radiotherapy. Eur J Cancer 1995; 31(A): 2260-2263.Google Scholar
  15. 15.
    Fayers P, Aaronson NK, Bjordal K, Sullivan M. EORTC QLQ-C30 Scoring Manual. Belgium: EORTC Data Center, 1995.Google Scholar
  16. 16.
    List MA, Stracks J. Evaluation of quality of life in patients definitively treated for squamous carcinoma of the head and neck. Curr Opin Oncol 2000; 12: 215-220.Google Scholar
  17. 17.
    Jansma J, Vissink A, Spijkervert FKL, et al. Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiation therapy. Cancer 1992; 70: 2171-2180.Google Scholar
  18. 18.
    Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al. Quality of life in head and neck cancer patients: Validation of the European Organization for Research and Treatment of Cancer Quality of life questionnaire-H&N 35. J Clin Oncol 1999; 17: 1008-1019.Google Scholar
  19. 19.
    Epstein JB, Robertson M, Emerton S, Philips N, Stevenson-Moore P. Quality of life and oral function in patients treated with radiation therapy for head and neck cancer. Head Neck 2001; 23: 389-398.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • M. Bansal
    • 1
  • B.K. Mohanti
    • 1
  • N. Shah
  • R. Chaudhry
    • 2
  • S. Bahadur
    • 3
  • N.K. Shukla
    • 4
  1. 1.Department of Radiation OncologyInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS)New DelhiIndia
  2. 2.Department of Microbiology, IRCH, AIIMSNew DelhiIndia
  3. 3.Department of Otolaryngology and Head and Neck Surgery, IRCH, AIIMSNew DelhiIndia
  4. 4.Department of Surgical Oncology, IRCH, AIIMSNew DelhiIndia

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