Pharmaceutical Research

, Volume 21, Issue 8, pp 1362–1373 | Cite as

Effects of the Chemical Structure and the Surface Properties of Polymeric Biomaterials on Their Biocompatibility

  • You-Xiong Wang
  • John L. Robertson
  • William B. SpillmanJr.
  • Richard O. Claus


Polymeric biomaterials have extensively been used in medicinal applications. However, factors that determine their biocompatibility are still not very clear. This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including protein adsorption, cell adhesion, cytotoxicity, blood compatibility, and tissue compatibility. Understanding these aspects of biocompatibility is important to the improvement of the biocompatibility of existing polymers and the design of new biocompatible polymers.

biocompatibility biomaterial blood compatibility cell adhesion cytotoxicity polymer protein adsorption surface property tissue compatibility 


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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • You-Xiong Wang
    • 1
  • John L. Robertson
    • 2
  • William B. SpillmanJr.
    • 3
  • Richard O. Claus
    • 1
  1. 1.Fiber & Electro-Optics Research CenterVirginia TechBlacksburgUSA
  2. 2.Department of Biomedical Sciences and PathobiologyVirginia-Maryland Regional College of Veterinary MedicineBlacksburgUSA
  3. 3.Virginia Tech Applied Biosciences CenterVirginia TechBlacksburgUSA

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