Neurochemical Research

, Volume 29, Issue 5, pp 1017–1038 | Cite as

Chemokines and Glial Cells: A Complex Network in the Central Nervous System

  • Elena AmbrosiniEmail author
  • Francesca Aloisi


Chemokines are small secreted proteins that are essential for the recruitment and activation of specific leukocyte subsets at sites of inflammation and for the development and homeostasis of lymphoid and nonlymphoid tissues. During the past decade, chemokines and their receptors have also emerged as key signaling molecules in neuroinflammatory processes and in the development and functioning of the central nervous system. Neurons and glial cells, including astrocytes, oligodendrocytes, and microglia, have been identified as cellular sources and/or targets of chemokines produced in the central nervous system in physiological and pathological conditions. In this article, we provide an update of chemokines and chemokine receptors expressed by glial cells focusing on their biological functions and implications in neurological diseases.

Astrocytes chemokines glial activation inflammation microglia neurodegeneration oligodendrocytes 


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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  1. 1.Department of Cell Biology and NeuroscienceIstituto Superiore di SanitáRomeItaly

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