Journal of Neuro-Oncology

, Volume 65, Issue 2, pp 167–172 | Cite as

Response of Neoplastic Meningitis from Solid Tumors to Oral Capecitabine

  • Pierre Giglio
  • Ivo W. Tremont-Lukats
  • Morris D. Groves


Neoplastic meningitis (NM) is a major challenge for the neuro-oncologist as it constitutes a relatively common clinical problem in systemic and central nervous system cancers, and is very difficult to treat. NM portends a significant worsening in prognosis. Chemotherapeutic treatment options are limited, and not particularly effective. We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil. We believe capecitabine warrants further investigation in patients with NM. In some patients, its use may result in clinical and radiographic tumor responses, improved quality of life, and possibly increased survival.

breast cancer capecitabine chemotherapy gastroesophageal cancer neoplastic meningitis 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Pierre Giglio
    • 1
  • Ivo W. Tremont-Lukats
    • 1
  • Morris D. Groves
    • 1
  1. 1.Neuro-Oncology DepartmentUniversity of Texas – M.D. Anderson Cancer CenterUSA

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