Quantitative Characterization of the Cellular Elements of Human Cerebellar Nuclei at Different Ages
- 24 Downloads
A quantitative assessment of the cellular elements present in the nuclei of the human cerebellum was performed using subjects aged 22–90 years. A series of horizontal sections of cerebellar nuclei was studied, stained with hematoxylin and eosin. The numbers of neurons and gliocytes per unit area were measured on sections, with subsequent calculation of their ratios (the glial index). These experiments showed that aging is associated with decreases in the content of neurons and increases in the content of gliocytes. The extent of these changes increases as ontogenesis proceeds.
Unable to display preview. Download preview PDF.
- 1.G. G. Avtandilov, Medical Morphometry[in Russian], Meditsina, Moscow (1990).Google Scholar
- 2.A. S. Amatuni, Functional Organization and Involvement of the Central Nuclei in the Integrative Activity of the Cerebellum [in Russian], Armenian Academy of Sciences Press, Erevan (1987).Google Scholar
- 4.N. V. Malinovskaya, Morphohistochemical Characteristics of the 'Neuron-Glia-Capillary' System and Lipid Peroxidation in the Basal Nuclei of the Human Brain in Aging[in Russian], Author's Abstract for Doctorate in Medical Sciences, Moscow (2003).Google Scholar
- 5.E. V. Mikhailova, Interaction of Morphohistochemical Parameters of the 'Neuron-Glia-Capillary' System with Lipid Peroxidation Processes in the Cortical Ends and Subcortical Centers of the Visual, Auditory, and Olfactory Analyzers[in Russian], Author's Abstract for Doctorate in Medical Sciences, Ufa (2000).Google Scholar
- 6.É. A. Oganesyan and G. Reim, “Characteristics of the responses of neurons in the central nuclei of the cerebellum of the conscious cat to hippocampal influences,” in Proceedings of the All-Union Symposium “Structural and Functional Organization of the Cere-bellum” [in Russian], Academy of Sciences of the Armenian SSR Press, Erevan (1984).Google Scholar
- 7.A. I. Roitbak, The Glia and Their Role in Nervous Activity[in Russian], Nauka, St. Petersburg (1993).Google Scholar
- 8.L. K. Semenova, V. A. Vasil'eva, I. A. Momot, et al., “The ensemble organization of the cerebral cortex and cerebellar cortex in relation to the development of movements during ontogenesis,” in: Proceedings of the XI Congress of Anatomists, Histologists, and Embryologists [in Russian], Poltava (1992).Google Scholar
- 9.O. S. Sotnikov, “Questions of neuroglial relationships. Discussions at the Congress 'The Function of the Neuroglia',” Arkh. Anat., 76, No. 6, 97–99 (1979).Google Scholar
- 10.L. D. Starlychanova, “Comparative characterization of the cyto-and angioarchitectonics of the lower olive and dentate nuclei of the cere-bellum during prenatal ontogenesis in humans,” Arkh. Anat., 76, 5–9 (1979).Google Scholar
- 13.T. A. Tsekhmistrenko and V. A. Vasilyeva, “Structural transformation of cerebral and cerebellar cortex in children from birth to six years of age as the morphological basis of visual function develop-ment,” Hum. Physiol., 22, No. 5, 575–581 (1996).Google Scholar