Molecular and Cellular Biochemistry

, Volume 264, Issue 1–2, pp 99–102

Integrative signaling in angiogenesis

  • Michael Simons


Angiogenesis is a complex process requiring integration of multiple signals in order to achieve successful development of the new vasculature. While individual activities of numerous growth factors are well understood, the integration of their signaling at the cellular and tissue level is just beginning to be appreciated. This review focuses on these two process using vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) as examples. (Mol Cell Biochem 264: 99–102, 2004)

growth factors FGF VEGF arteriogenesis 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Michael Simons
    • 1
  1. 1.Angiogenesis Research Center and Section of CardiologyDartmouth Medical School, Dartmouth-Hitchcock Medical CenterLebanonUSA

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