Molecular and Cellular Biochemistry

, Volume 255, Issue 1–2, pp 57–66 | Cite as

Molecular mechanisms of arsenic carcinogenesis

  • Chuanshu Huang
  • Qingdong Ke
  • Max Costa
  • Xianglin Shi
Article

Abstract

Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.

arsenic carcinogenesis gene expressin reactive oxygen species genetic toxicity signal transduction kinase methylation 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Chuanshu Huang
    • 1
  • Qingdong Ke
    • 1
  • Max Costa
    • 1
  • Xianglin Shi
    • 2
  1. 1.Nelson Institute of Environmental Medicine, New York University School of MedicineTuxedoUSA
  2. 2.Health Effects Laboratory Division, National Institute for Occupational Safety and HealthMorgantownUSA

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