Journal of Mammary Gland Biology and Neoplasia

, Volume 8, Issue 4, pp 383–394

Integrins in Mammary Gland Development and Differentiation of Mammary Epithelium

  • Ilaria Taddei
  • Marisa M. Faraldo
  • Jérôme Teulière
  • Marie-Ange Deugnier
  • Jean Paul Thiery
  • Marina A. Glukhova
Article

Abstract

Integrins are major extracellular matrix (ECM) receptors that can also serve for some cell–cell interactions. They have been identified as important regulators of mammary epithelial cell growth and differentiation. Their ability to promote cell anchorage, proliferation, survival, migration, and the induction of active ECM-degrading enzymes suggests that they play an essential role in normal mammary morphogenesis, but, on the other hand, reveals their potential to promote tumor progression.

integrins mammary epithelium differentiation morphogenesis tumor progression 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Ilaria Taddei
    • 1
  • Marisa M. Faraldo
    • 1
  • Jérôme Teulière
    • 1
  • Marie-Ange Deugnier
    • 1
  • Jean Paul Thiery
    • 1
  • Marina A. Glukhova
    • 1
  1. 1.UMR 144 CNRS-Institut Curie, Section de RechercheParis Cedex 05France

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