Journal of Fluorescence

, Volume 14, Issue 4, pp 391–400 | Cite as

Saccharide Sensing Using Gold and Silver Nanoparticles-A Review

  • Kadir Aslan
  • Jian Zhang
  • Joseph R. Lakowicz
  • Chris D. Geddes


We review new methodologies for glucose sensing from our laboratories based on the specific biological interactions between Con A, dextran-coated gold nanoparticles and glucose, and the interactions between dextran, glucose, and boronic-acid capped silver nanoparticles in solution. Our new approaches promise new tunable glucose sensing platforms. Dextran-coated gold nanoparticles were aggregated with the addition of Con A resulting in increase an in absorbance of nanoparticles at 650 nm, where the post-addition of glucose caused the dissociation of the aggregates and thus a decrease in the absorbance at 650 nm. The interaction of glucose and dextran with boronic acid-capped silver nanoparticles in solution resulted in enhanced luminescence intensity cumulatively due to surface-enhanced fluorescence and the decrease in absorbance at 400 nm, with an increase in absorbance at 640 nm. Lifetime measurements were used to distinguish the contribution from the surface-enhanced fluorescence. TEM was employed to assess the aggregation of nanoparticles.

Gold colloids silver colloids glucose sensing nanosensors monosaccharide polysaccharide plasmons surface plasmon resonance 


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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Kadir Aslan
    • 1
    • 2
  • Jian Zhang
    • 2
  • Joseph R. Lakowicz
    • 2
  • Chris D. Geddes
    • 1
  1. 1.Institute of Fluorescence and Center for Fluorescence Spectroscopy, Medical Biotechnology CenterUniversity of Maryland Biotechnology InstituteBaltimore
  2. 2.Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular BiologyUniversity of Maryland School of MedicineBaltimore

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