Journal of Combinatorial Optimization

, Volume 7, Issue 4, pp 339–352 | Cite as

Random Pooling Designs Under Various Structures

  • F.K. Hwang
  • Y.C. Liu


Balding et al. (1995) showed that randomizing over the k-set space yields much better pooling designs than the random pooling design without the k-restriction. A natural question arises as to whether a smaller subspace, i.e., a space with more structure, will yield even better results. We take the random subset containment design recently proposed by Macula, which randomizes over a subspace of the k-set space, as our guinea pig to compare with the k-set space. Unfortunately the performance of the subset containment design is hard to analyze and only approximations are given. For a set of parameters, we are able to produce either an exact analysis or very good approximations. The comparisons under these parameters seem to favor the k-set space.

random pooling designs clone library screening k-clique 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • F.K. Hwang
    • 1
  • Y.C. Liu
    • 1
  1. 1.Department of Applied MathematicsNational Chiao Tung UniversityHsinchuTaiwan, ROC

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