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Detection of micro- and nano-sized biocompatible particles in the blood

  • A. M. Gatti
  • S. Montanari
  • E. Monari
  • A. Gambarelli
  • F. Capitani
  • B. Parisini
Article

Abstract

The research deals with new scanning electron microscopic evaluations of the interface between blood and explanted temporary vena cava filters from patients affected by blood disorders. The biological tissues adherent to the filter and the small thrombi formed in vivo were detached from the metallic structure of the device, fixed, dehydrated and prepared for the histological and the electron microscopy. The analyses showed that both samples (thrombus and newly formed tissue) contained foreign, in some cases nano-sized, bodies. The chemistry of these particles was different and varied, and unusual compounds containing non-biocompatible elements like bismuth, lead, wolfram, tungsten were also detected. The interaction between these debris travelling in the blood stream and the blood itself leads to suspect that the formation of the thrombus can originate from these inorganic and inert foreign bodies that act as triggering agent of the blood coagulation.

Keywords

Polymer Microscopy Electron Microscopy Tungsten Bismuth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    European Standard EN 30993, Biological Testing of dental and Medical Devices No. 4, Selection of Tests for Interactions with Blood (1993).Google Scholar
  2. 2.
    M. Ballestri, A. Baraldi, A. M. Gatti, L. Furci, A. Bagni, P. Loria, R. Rapanà, N. Carulli and A. Albertazzi, Gastroenterology 121 (2001) 1234.Google Scholar
  3. 3.
    A. M. Gatti and F. Rivasi, Biomaterials 23 (2002) 2381.Google Scholar
  4. 4.
    A. M. Gatti, ibid. (2003) (in press).Google Scholar
  5. 5.
    A. Nemmar, P. H. Hoet, B. Vanquickenborne, D. Dinsdale, M. Thomeer, M. F. Hoylaerts, H. Vanbiloen and B. Nemery, Circulation 105 (2002) 411.Google Scholar
  6. 6.
    P. A. Revell and A. L. Saffar, J. Long Term Effects of Med. Impl. 9 (1999) 319.Google Scholar
  7. 7.
    R. Urban, J. Jacobs and M. Tomlinson, J. Bone Jt Surg. 82 (2000) 455.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • A. M. Gatti
    • 1
  • S. Montanari
    • 1
  • E. Monari
    • 1
  • A. Gambarelli
    • 1
  • F. Capitani
    • 1
  • B. Parisini
    • 1
  1. 1.INFM, Laboratorio dei Biomateriali, Dipartimento di Neuroscienze, Testa Collo, RiabilitazioneUniversità di Modena e Reggio EmiliaModenaItaly

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