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Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration

  • R. G. J. C. Heijkants
  • R. V. van Calck
  • J. H. de Groot
  • A. J. Pennings
  • A. J. SchoutenEmail author
  • T. G. van Tienen
  • N. Ramrattan
  • P. Buma
  • R. P. H. Veth
Article

Abstract

Longitudinal lesions in menisci are among the most frequent orthopedic problems of the knee. Repair by simple techniques is only limited to the vascular part of the meniscus. For repair of the avascular part of the meniscus a scaffold, which will assist the body in the formation of new meniscus cell tissue, might be applicable. In this study a biomedical segmented polyurethane with poly(ε-caprolactone) as soft segment and 1,4-butanediisocyanate and 1,4-butanediol as uniform hard segments has been synthesised. The material has a micro phase separated morphology and excellent mechanical properties. A porous scaffold was prepared via a combination of liquid–liquid phase separation and salt leaching. The foams prepared combined a very high interconnectivity and porosity with the desired compression modulus. After six months of implantation in the knees of beagles full ingrowth with cells was obtained and it was found that meniscus like tissue had been formed in the scaffold. Moreover, compression behaviour appeared to be comparable to native meniscus tissue.

Keywords

Polyurethane Hard Segment Soft Segment Liquid Phase Separation Meniscus Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. Klompmaker, H. W. B. Jansen, R. P. H. Veth, J. H. De Groot, A. J. Pennings and R. Kuijer, Biomaterials 12 (1992) 810.Google Scholar
  2. 2.
    J. Klompmaker, H. W. B. Jansen, R. P. H. Veth, J. H. De Groot, A. J. Pennings and R. Kuijer, J. Orthop. Res. 10 (1992) 359.Google Scholar
  3. 3.
    J. H. De Groot, F. M. Zijlstra, H. W. Kuipers, A. J. Pennings, J. Klompmaker, R. P. H. Veth and H. W. B. Jansen, Biomaterials 18 (1997) 613.Google Scholar
  4. 4.
    J. H. De Groot, A. J. Nijenhuis, P. Bruin, A. J. Pennings, R. P. H. Veth, J. Klompmaker and H. W. B. Jansen, Coll. Poly. Sci. 268 (1990) 1071.Google Scholar
  5. 5.
    R. E. Marchant, Q. Zhao, J. M. Anderson and A. Hiltner, Polymer 28 (1987) 2032.Google Scholar
  6. 6.
    C. J. Spaans, J. H. De Groot, V. W. Belgraver and A. J. Pennings, J. Mat. Sci. Mat. Med. 9 (1998) 675.Google Scholar
  7. 7.
    J. H. De Groot, A. J. Pennings, C. J. Spaans, B. S. Wildeboer and R. De Vrijer, Pol. Bull. 38 (1997) 211.Google Scholar
  8. 8.
    C. W. Tabor and H. Tabor, Ann. Rev. Biochem. 53 (1984) 749.Google Scholar
  9. 9.
    T. G. Van Tienen, R. G. J. C. Heijkants, P. Buma, J. H. De Groot, A. J. Schouten and R. P. H. Veth, Gen. Orthop. Surg. (2003) (in press).Google Scholar
  10. 10.
    T. G. Tienen, R. G. J. C. Heijkants, P. Buma, J. H. De Groot, A. J. Pennings and R. P. H. Veth, Biomaterials 24 (2003) 2541.Google Scholar
  11. 11.
    A. Goris, Ann. Pharm. Fr. 24 (1968) 781.Google Scholar
  12. 12.
    R. J. Goris, Unfallchirurgie 88 (1985) 330.Google Scholar
  13. 13.
    R. J. Goris, L. M. Dongen and H. A. Winters, Free Radic. Res. Commun. 3 (1987) 13.Google Scholar
  14. 14.
    M. J. Miles, in “Developments in Crystalline Polymers -2” (Elsevier Applied Science, London, 1988) pp. 233-295.Google Scholar
  15. 15.
    F. N. Ghadially, L. Thomas, N. Yong and J. M. Lalonde, J. Anat. 125 (1978) 499.Google Scholar
  16. 16.
    C. A. McDevitt and R. J. Webber, Clin. Orthop. Rel. Res. 252 (1990) 8.Google Scholar
  17. 17.
    R. J. Webber, M. G. Harris and A. J. J. Hough, J. Orthop. Res. 3 (1985) 171.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • R. G. J. C. Heijkants
    • 1
  • R. V. van Calck
    • 1
  • J. H. de Groot
    • 1
  • A. J. Pennings
    • 1
  • A. J. Schouten
    • 1
    Email author
  • T. G. van Tienen
    • 2
  • N. Ramrattan
    • 2
  • P. Buma
    • 2
  • R. P. H. Veth
    • 2
  1. 1.Department of Polymer Chemistry, Faculty of Mathematics and Natural SciencesState University of GroningenGroningenThe Netherlands
  2. 2.Orthopaedic Research LaboratoryUniversity Medical CenterNijmegenThe Netherlands

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