Influence of octacalcium phosphate coating on osteoinductive properties of biomaterials

  • P. Habibovic
  • C. M. van der Valk
  • C. A. van Blitterswijk
  • K. de Groot
  • G. Meijer


In this study, we investigated the influence of octacalcium phosphate (OCP) coating on osteoinductive behaviour of the biomaterials. Porous titanium alloy (Ti6Al4V), hydroxyapatite (HA), biphasic calcium phosphate (BCP) and polyethylene glyco terephtalate/polybuthylene terephtalate (PEGT–PBT) copolymer, all uncoated and coated with biomimetically produced OCP, were implanted in back muscles of 10 goats for 6 and 12 weeks. Uncoated Ti6Al4V and HA did not show any bone formation after intramuscular implantation. All OCP coated implants, except PEGT–PBT, did induce bone in the soft tissue. The reason for the non-inductive behaviour of the copolymer is probably its softness, that makes it impossible to maintain its porous shape after implantation. Both uncoated and OCP coated BCP induced bone. However, the amount of animals in which the bone was induced was higher in the coated BCP implants in comparison to the uncoated ones. Osteoinductive potential of biomaterials is influenced by various material characteristics, such as chemical composition, crystallinity, macro- and microstructure. OCP coating has a positive effect on osteoinductivity of the biomaterials. The combination of the advantages of biomimetic coating method above traditional methods, and a good osteoinductivity of OCP coating that is produced by using this method, opens new possibilities for designing more advanced orthopaedic implants.


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • P. Habibovic
    • 1
    • 2
  • C. M. van der Valk
    • 2
  • C. A. van Blitterswijk
    • 1
    • 2
  • K. de Groot
    • 1
    • 2
  • G. Meijer
    • 3
  1. 1.Institute of Biomedical TechnologyTwente University, Department Bilthoven, Professor Bronkhorstlaan 10-DBilthovenThe Netherlands
  2. 2.IsoTis SA, BilthovenThe Netherlands
  3. 3.University Medical Center UtrechtThe Netherlands

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