Journal of Computational Neuroscience

, Volume 16, Issue 1, pp 5–13 | Cite as

Dendritic I h Selectively Blocks Temporal Summation of Unsynchronized Distal Inputs in CA1 Pyramidal Neurons

  • M. Migliore
  • L. Messineo
  • M. Ferrante


The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, I h , in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the I h in these neurons is needed to reduce neuronal excitability selectively for distal unsynchronized, but not for synchronized, inputs.

dendritic integration Ih CA1 modeling 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • M. Migliore
    • 1
    • 2
  • L. Messineo
    • 3
  • M. Ferrante
    • 3
  1. 1.Department of NeurobiologyYale University School of MedicineNew HavenUSA
  2. 2.Institute of Biophysics, National Research CouncilPalermoItaly
  3. 3.Department of PsychologyUniversity of PalermoPalermoItaly

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