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Journal of Assisted Reproduction and Genetics

, Volume 21, Issue 10, pp 361–366 | Cite as

Serum Leptin Elevation in Obese Women with PCOS: A Continuing Controversy

  • Hisham Ali Saleh
  • Mohamed Amr El-Nwaem
  • Magdy Mamdouh El-Bordiny
  • Hala Mohamed El-Sayed Maqlad
  • Amr Ahmed El-Mohandes
  • Ebtehag Mohamed Eldaqaq
Article

Abstract

Purpose: To evaluate leptin levels in a sample of obese women with PCOS and compare the results with obese and non-obese control, to be ultimately correlated with BMI, and insulin sensitivity.

Methods: Leptin and insulin assays by immuno-radiometric method, glucose assay by enzymatic colorimetric method.

Results: Leptin levels were significantly different between obese and non-obese subjects, and were significantly different between insulin resistant and non-insulin resistant obese PCOS, but were not significantly different between obese non-insulin resistant PCOS, and obese controls.

Conclusions: Body mass index and insulin resistance are the two main factors governing serum leptin levels.

Body mass index leptin obesity polycystic ovary syndrome 

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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Hisham Ali Saleh
    • 1
    • 2
  • Mohamed Amr El-Nwaem
    • 3
  • Magdy Mamdouh El-Bordiny
    • 2
  • Hala Mohamed El-Sayed Maqlad
    • 3
  • Amr Ahmed El-Mohandes
    • 3
  • Ebtehag Mohamed Eldaqaq
    • 3
  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineAlexandria UniversityAlexandriaEgypt
  2. 2.Department of Clinical Pathology, Faculty of MedicineAlexandria UniversityAlexandriaEgypt
  3. 3.Department of Physiology, Faculty of MedicineAlexandria UniversityAlexandriaEgypt

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