Journal of Molecular Histology

, Volume 35, Issue 3, pp 247–253 | Cite as

IGF-I Receptor, Cell–Cell Adhesion, Tumour Development and Progression

  • Loredana Mauro
  • Eva Surmacz


The insulin-like growth factor I receptor (IGF-IR) has been implicated in the development and progression of many common cancers and other neoplastic diseases. The tumorigenic potential of IGF-IR relies on its antiapoptotic and transforming activities. The molecular mechanisms by which IGF-IR controls the proliferation and survival of tumour cells have been extensively studied and many pathways have been delineated. However, the role of IGF-IR in the regulation of non-mitogenic cell functions is less well understood. Here we focus on IGF-IR-dependent cell–cell adhesion. Limited studies suggested that IGF-IR can regulate cell aggregation and intercellular adhesion mediated by cadherins and cadherin-associated proteins. We review the mechanisms of this process and discuss the impact of IGF-IR-dependent cell–cell adhesion on the phenotype of tumour cells.


Tumour Cell Growth Factor Molecular Mechanism Cell Adhesion Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Loredana Mauro
    • 1
  • Eva Surmacz
    • 2
  1. 1.Department of Cellular Biology and Faculty of PharmacyUniversity of CalabriaRendeItaly
  2. 2.Kimmel Cancer InstituteThomas Jefferson UniversityPhiladelphiaUSA;

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