Glycoconjugate Journal

, Volume 20, Issue 3, pp 207–212 | Cite as

Role of N-glycans in growth factor signaling

  • Motoko Takahashi
  • Takeo Tsuda
  • Yoshitaka Ikeda
  • Koichi Honke
  • Naoyuki Taniguchi
Article

Abstract

Secreted proteins and membrane proteins are frequently post-translationally modified by oligosaccharides. Therefore, many glycoproteins are involved in signal transduction. One example is growth factor receptors, which are membrane proteins that often contain oligosaccharides. The oligosaccharides in those growth factor receptors play crucial roles in receptor functions. An analysis of glycosyltransferase-transfectants revealed that the branching structures of oligosaccharide also serve as important determinants. For example, N-glycans of epidermal growth factor receptor (EGFR) are involved in receptor sorting, ligand binding and dimerization. The addition of a bisecting GlcNAc to N-glycans increases the endocytosis of EGFR. N-glycans of Trk, a high affinity nerve growth factor receptor, also affect its function. Thus, oligosaccharides play an important role in growth factor signaling. Published in 2004.

EGF (epidermal growth factor) EGFR (EGF receptor) NGF (nerve growth factor) Trk insulin IR (insulin receptor) glycosyltransferase 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Motoko Takahashi
    • 1
  • Takeo Tsuda
    • 1
  • Yoshitaka Ikeda
    • 1
  • Koichi Honke
    • 1
  • Naoyuki Taniguchi
    • 1
  1. 1.Department of BiochemistryOsaka Univerisity Graduate School of MedicineSuita, OsakaJapan

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