Glycoconjugate Journal

, Volume 19, Issue 7–9, pp 615–619 | Cite as

The involvement of galectin-1 in skeletal muscle determination, differentiation and regeneration

  • Diana J. Watt
  • Gareth E. Jones
  • Kirstin Goldring

Abstract

The dogma that a cell is rigidly committed to one tissue type has been heavily challenged over the past few years with numerous reports of transdifferentiation of cells between different lineages. Cells capable of entering lineages other than that of their tissue of origin have been identified in several diverse tissues. Recently we have focussed on a non-committed myogenic cell within the dermis that is capable, under certain conditions, of expressing muscle specific markers and even fusing to the terminally differentiated stage of muscle cell development. We have identified galectin-1 as being a potent factor implicated in this process. In this review we discuss our findings and consider the involvement of galectin-1 in muscle determination, differentiation and regeneration. Published in 2004.

galectin-1 muscle development dermal fibroblasts 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Diana J. Watt
    • 1
  • Gareth E. Jones
    • 2
  • Kirstin Goldring
    • 3
  1. 1.Department of AnatomyBrighton and Sussex Medical SchoolBrighton, East SussexUK
  2. 2.Randall Centre for Molecular Mechanisms of Cell FunctionKing's College LondonLondonUK
  3. 3.UK Parkinson's Disease Society Tissue Bank at Imperial College, Division of Neuroscience & Psychological MedicineImperial College Faculty of MedicineLondonUK

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