Glycoconjugate Journal

, Volume 19, Issue 7–9, pp 543–549 | Cite as

Galectin-3 and metastasis

  • Yukinori Takenaka
  • Tomoharu Fukumori
  • Avraham Raz
Article

Abstract

Galectin-3, a 31 kDa member of the β-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and metastasis. Galectin-3 is involved in various biological phenomena including cell growth, adhesion, differentiation, angiogenesis and apoptosis. Recent research revealed that galectin-3 is associated with several steps of invasion and metastasis, like angiogenesis, cell-matrix interaction, dissemination through blood flow and extravasation. Recently, we and others have shown that galectin-3 can be a reliable diagnostic marker in certain cancers and one of the target proteins of cancer treatment. In this review, we describe the involvement of galectin-3 in each steps of metastasis and clinical significance of galectin-3. Published in 2004.

galectin-3 metastasis cancer 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Yukinori Takenaka
    • 1
  • Tomoharu Fukumori
    • 1
  • Avraham Raz
    • 1
  1. 1.Tumor Progression and Metastasis Program, Karmanos Cancer InstituteWayne State UniversityDetroitUSA

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