Investigational New Drugs

, Volume 22, Issue 1, pp 91–97 | Cite as

Gemcitabine and Cisplatin for Patients with Metastatic or Recurrent Esophageal Carcinoma: A Southwest Oncology Group Study

  • Susan G. Urba
  • Kari Chansky
  • Peter J. vanVeldhuizen
  • Robert E. Pluenneke
  • Jacqueline K. Benedetti
  • John S. Macdonald
  • James L. Abbruzzese
Article

Abstract

Purpose: Experimental data, both in vivo and in vitro, suggest that the combination of gemcitabine and cisplatin acts synergistically. Within the Southwest Oncology Group, we designed a Phase II trial to test this chemotherapy combination for patients with esophageal cancer. Experimental design: Patients with metastatic or recurrent esophageal cancer were treated with gemcitabine 1000 mg/m2 on days 1, 8, and 15, and cisplatin 100 mg/m2 on day 15. Cycles were repeated every 28 days. The statistical endpoint was overall survival. Results: Sixty-four eligible patients were accrued from 37 institutions. Twenty-six percent of patients had prior chemotherapy. The treatment was generally well-tolerated, with the most common toxicity being neutropenia in 31% of patients. All 64 patients have died. Survival at 3 months was 81%, and at 1 year was 20%. Median survival was 7.3 months. Conclusions: This regimen is tolerable palliative option for patients with metastatic esophageal cancer.

esophageal cancer chemotherapy gemcitabine cisplatin 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Susan G. Urba
    • 1
  • Kari Chansky
    • 2
  • Peter J. vanVeldhuizen
    • 3
  • Robert E. Pluenneke
    • 4
  • Jacqueline K. Benedetti
    • 2
  • John S. Macdonald
    • 5
  • James L. Abbruzzese
    • 6
  1. 1.University of Michigan Medical CenterAnn ArborU.S.A.
  2. 2.Southwest Oncology Group Statistical CenterSeattleU.S.A
  3. 3.University of Kansas Medical CenterKansas City
  4. 4.Kansas City Community Clinical Oncology ProgramKansas City
  5. 5.St Vincent's Comprehensive Cancer CenterNew YorkU.S.A
  6. 6.MD Anderson Cancer CenterHoustonU.S.A

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