Digestive Diseases and Sciences

, Volume 49, Issue 9, pp 1425–1432 | Cite as

Are Helicobacter Species and Enterotoxigenic Bacteroides fragilis Involved in Inflammatory Bowel Disease?

  • Christelle Basset
  • John Holton
  • Alexandra Bazeos
  • Dino Vaira
  • Stuart Bloom


The aim of this study was to determine if either Helicobacter or enterotoxigenic Bacteroides fragilis (ETBF) was linked to inflammatory bowel disease (IBD), using PCR. We analyzed the luminal washings and colonic biopsies of 35 patients with IBD and 37 control patients. The presence of Helicobacter was confirmed in the luminal washing of one IBD patient and three control patients and in the biopsies of two IBD patients. Ten of 28 control patients and 8 of 32 IBD patients had a positive luminal washing for the enterotoxin gene. Six of 33 control patients and 4 of 32 IBD patients had positive biopsies. The prevalence of the enterotoxin gene was higher in IBD patients with active disease compared with patients with inactive disease, although it did not achieve statistical significance. In conclusion, Helicobacter was not associated with IBD in our population of patients, although ETBF may be associated with active disease.

Helicobacter Bacteroides IBD diarrhea 


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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Christelle Basset
    • 1
  • John Holton
    • 1
  • Alexandra Bazeos
    • 1
  • Dino Vaira
    • 2
  • Stuart Bloom
    • 2
  1. 1.Centre for Infectious Diseases and International HealthRoyal Free & University College London Medical SchoolLondonUnited Kingdom
  2. 2.Department of Internal Medicine and GastroenterologyUniversity of BolognaBolognaItaly

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