Digestive Diseases and Sciences

, Volume 49, Issue 7–8, pp 1088–1090 | Cite as

Oral Broccoli Sprouts for the Treatment of Helicobacter pylori Infection: A Preliminary Report

  • Mark V. Galan
  • Arfana A. Kishan
  • Ann L. Silverman


We sought to determine whether orally consumed broccoli sprouts could eradicate Helicobacter pylori infection in infected human volunteers. Helicobacter pylori-positive patients were identified by stool antigen testing or gastric biopsies. Patients consumed broccoli sprouts (14, 28, or 56 g) twice daily for 7 days. We performed stool antigen testing immediately following the completion of treatment (day 8) and at day 35. Urea breath testing was performed on those patients who remained negative at day 35. Patients completed pre- and posttreatment questionnaires regarding symptoms (abdominal discomfort—pain, nausea, bloating), recent medications, and palatability. Nine patients completed the course of treatment and began follow-up testing. Seven of nine (78%) patients were stool antigen negative immediately after the completion of therapy and six remained negative at day 35. Urea breath testing was completed on six patients. Two patients were negative, two positive, and two indeterminate. Endoscopic gastric biopsies were obtained from one patient with an indeterminate breath test and the tissue was negative for H. pylori by immunohistochemical staining. Of the five patients who provided information on pre- and posttreatment symptoms, two reported improvement, one no change, and one reported worsening. Six patients rated the taste of broccoli sprouts from okay to very good; one patient stated they were “not good.” Consumption of oral broccoli sprouts was temporally associated with eradication of H. pylori infection in three of nine patients. Most patients found broccoli sprouts palatable. Further studies are needed to determine the optimal dose of broccoli sprouts and whether concomitant proton pump inhibitors or antibiotics might augment the effectiveness.

Helicobacter pylori broccoli sprouts 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Torres J, Leal-Herrera Y, Perez-Perez G, et al.: A community-based seroepidemiologic study of Helicobacter pyloriinfection inMexico. J Infect Dis 178:1089–1094, 1998Google Scholar
  2. 2.
    Fahey JW, HaristoyX, Dolan PM, et al.: Sulforaphane inhibits extracellular, intracellular and antibiotic-resistant strains of Helicobacter pyloriand prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA 99:7610–7615, 2002Google Scholar
  3. 3.
    Fahey JW, Zalcmann AT, Talalay P: The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry56:5–51, 2001Google Scholar
  4. 4.
    Shapiro TA, Fahey JW, Wade KL, et al.: Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans. Cancer Epidemiol Biomark Prev10:501–508, 2001Google Scholar
  5. 5.
    Shapiro TA, Fahey JW, Wade KL, et al.: Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomark Prev7:1091–1100, 1998Google Scholar
  6. 6.
    Fahey JW, Zhang Y, Talalay P: Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci USA94:10367–10372, 1997Google Scholar
  7. 7.
    Talalay P, Fahey JW, Holtzclaw WD, et al.: Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett 82-83:173–179, 1995Google Scholar
  8. 8.
    Dornberger K, Bockel V, Heyer J, et al.: Investigations of the isothiocyanates erysolin and sulforaphan of Cardaria draba L. Pharmazie 30:792–796 </del>Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Mark V. Galan
    • 1
  • Arfana A. Kishan
    • 1
  • Ann L. Silverman
    • 1
  1. 1.The Division of Gastroenterology and HepatologyWilliam Beaumont HospitalRoyal OakUSA

Personalised recommendations