Digestive Diseases and Sciences

, Volume 49, Issue 3, pp 469–474 | Cite as

IBS-Like Symptoms in Patients with Inflammatory Bowel Disease in Remission; Relationships with Quality of Life and Coping Behavior

  • Itta M. Minderhoud
  • Bas Oldenburg
  • Josta A. Wismeijer
  • Gerard P. Van Berge Henegouwen
  • André J.P.M. Smout


The aim of this study was to assess the prevalence of irritable bowel syndrome-like symptoms in healthy controls and inflammatory bowel disease patients in remission using the Rome II criteria. Furthermore, the possible relation of irritable bowel syndrome-like symptoms with the quality of life and coping behavior was studied. Seventy-three ulcerative colitis patients in remission, 34 Crohn's disease patients in remission, and 66 healthy controls completed questionnaires on irritable bowel syndrome, quality of life, and coping. Using the Rome II criteria, irritable bowel syndrome-like symptoms were found in one-third of ulcerative colitis patients and in 42% of Crohn's disease patients in remission. The presence of irritable bowel syndrome-like symptoms impaired the quality of life of patients, while no relation was found between the presence of symptoms and coping strategies.

IBS-like symptoms Rome II criteria inflammatory bowel disease remission coping quality of life 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA: Functional bowel disorders and functional abdominal pain. Gut 45 (Suppl 2):II43-II47, 1999Google Scholar
  2. 2.
    Manning AP, Thompson WG, Heaton KW, Morris AF: Towards positive diagnosis of the irritable bowel. Br Med J 2:653-654, 1978Google Scholar
  3. 3.
    Boyce PM, Koloski NA, Talley NJ: Irritable bowel syndrome according to varying diagnostic criteria: Are the new Rome II criteria unnecessarily restrictive for research and practice? Am J Gastroenterol 95:3176-3183, 2000Google Scholar
  4. 4.
    Gwee KA, Graham JC, McKendrick MW, et al.: Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 20(347):150-153, 1996Google Scholar
  5. 5.
    Collins SM, Piche T, Rampal P: The putative role of inflammation in the irritable bowel syndrome. Gut 49:743-745, 2001Google Scholar
  6. 6.
    Simren M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J, Bjornsson ES: Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors. Am J Gastroenterol 97:389-396, 2002Google Scholar
  7. 7.
    Isgar B, Harman M, Kaye MD, Whorwell PJ: Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut 24:190-192, 1983Google Scholar
  8. 8.
    Whitehead WE, Burnett CK, Cook EW III, Taub E: Impact of irritable bowel syndrome on quality of life. Dig Dis Sci 41:2248-2253, 1996Google Scholar
  9. 9.
    O'Keefe EA, Talley NJ, Zinsmeister AR, Jacobsen SJ: Bowel disorders impair functional status and quality of life in the elderly: a population-based study. J Gerontol A Biol Sci Med Sci 50:M184-M189, 1995Google Scholar
  10. 10.
    Stam R, Akkermans LM, Wiegant VM: Trauma and the gut: interactions between stressful experience and intestinal function. Gut 40:704-709, 1997Google Scholar
  11. 11.
    Whitehead WE, Crowell MD, Robinson JC, Heller BR, Schuster MM: Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut 33:825-830, 1992Google Scholar
  12. 12.
    Endler NS, Parker JDA: Assessment of multidimensional coping: task, emotion, and avoidance strategies. Psychol Assess 6:50-60, 1994Google Scholar
  13. 13.
    Best WR, Becktel JM, Singleton JW, Kern F Jr: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 70:439-444, 1976Google Scholar
  14. 14.
    Lichtiger S, Present DH, Kornbluth A, et al.: Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 330:1841-1845, 1994Google Scholar
  15. 15.
    Guyatt G, Mitchell A, Irvine EJ, et al.: A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology 96:804-810, 1989Google Scholar
  16. 16.
    Russel MG, Pastoor CJ, Brandon S, et al.: Validation of the Dutch translation of the Inflammatory Bowel Disease Questionnaire (IBDQ): a health-related quality of life questionnaire in inflammatory bowel disease. Digestion 58:282-288, 1997Google Scholar
  17. 17.
    Fournier M, de Ridder D, Bensing JM: Optimism and adaption to multiple sclerosis: What does optimism mean. J Behav Med 22:303-326, 1999Google Scholar
  18. 18.
    Smári J, Valtysdóttir H: Dispositional coping, psychological distress and disease-control in diabetes. Person Indiv Diff 22:151-156, 1997Google Scholar
  19. 19.
    de Ridder D, Schreurs KM, Bensing JM. The relative benefits of being optimistic: optimism as a coping resource in multiple sclerosis and Parkinson's disease. Br J Health Psychol 5:141-155, 2000Google Scholar
  20. 20.
    de Ridder D, van Heck G: Handleiding CISS-NL [Manual CISS-NL]. In pressGoogle Scholar
  21. 21.
    Boekema PJ, van Dam van Isselt EF, Bots ML, Smout AJ: Functional bowel symptoms in a general Dutch population and associations with common stimulants. Neth J Med 59:23-30, 2001Google Scholar
  22. 22.
    Talley NJ, Boyce PM, Jones M: Predictors of health care seeking for irritable bowel syndrome: a population based study. Gut 41:394-398, 1997Google Scholar
  23. 23.
    Drossman DA, Li Z, Andruzzi E, et al.: U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 38:1569-1580, 1993Google Scholar
  24. 24.
    Talley NJ, Zinsmeister AR, Van Dyke C, Melton LJ III: Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 101:927-934, 1991Google Scholar
  25. 25.
    Talley NJ, O'Keefe EA, Zinsmeister AR, Melton LJ III: Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology 102:895-901, 1992Google Scholar
  26. 26.
    Cosnes J, Carbonnel F, Beaugerie L, Blain A, Reijasse D, Gendre JP: Effects of appendicectomy on the course of ulcerative colitis. Gut 51:803-807, 2002Google Scholar
  27. 27.
    Selby WS, Griffin S, Abraham N, Solomon MJ: Appendectomy protects against the development of ulcerative colitis but does not affect its course. Am J Gastroenterol 97:2834-2838, 2002Google Scholar
  28. 28.
    Drossman DA, Patrick DL, Mitchell CM, Zagami EA, Appelbaum MI: Health-related quality of life in inflammatory bowel disease. Functional status and patient worries and concerns. Dig Dis Sci 34:1379-1386, 1989Google Scholar
  29. 29.
    Irvine EJ, Feagan B, Rochon J, et al.: Quality of life: a valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Canadian Crohn's Relapse Prevention Trial Study Group. Gastroenterology 106:287-296, 1994Google Scholar

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Itta M. Minderhoud
    • 1
  • Bas Oldenburg
    • 1
  • Josta A. Wismeijer
    • 1
  • Gerard P. Van Berge Henegouwen
    • 1
  • André J.P.M. Smout
    • 1
  1. 1.The Department of GastroenterologyUniversity Medical Center UtrechtUtrechtThe Netherlands

Personalised recommendations