Digestive Diseases and Sciences

, Volume 48, Issue 12, pp 2237–2241 | Cite as

Clinical Symptoms in Endoscopic Reflux Esophagitis: Evaluation in 8031 Adult Subjects

  • Kazuyo Okamoto
  • Ryuichi Iwakiri
  • Mitsuru Mori
  • Megumi Hara
  • Kayoko Oda
  • Akiko Danjo
  • Akifumi Ootani
  • Hiroyuki Sakata
  • Kazuma FujimotoEmail author


This study aimed to evaluate the correlation between symptoms and endoscopic findings in reflux esophagitis. Subjects, 8031 persons without medication for gastrointestinal disease, were briefly asked about the presence of heartburn, dysphagia, odynophagia, and acid regurgitation by associated medical staff before endoscopy for assessment of esophagitis utilizing the Los Angeles Classification. Endoscopically, 1199 (14.9%) were classified as positive reflux esophagitis, and 2223 (27.7%) had heartburn, 1522 (19.0%) had dysphagia, 493 (6.1%) had odynophagia, and 1466 (18.3%) had acid regurgitation. Multivariate analysis indicated that the symptom most related to esophagitis was heartburn (odds ratio: 2.46), although ∼40% of subjects with grade C or D did not complain of heartburn. Regarding the other symptoms, less than 30% subjects with severe esophagitis complained of the symptoms and the odds ratio was ∼1. These results indicate that endoscopic esophagitis was not equivalent to any reflux symptoms from which subjects suffered in their daily lives.

heartburn dysphagia odynophagia acid regurgitation Los Angeles Classification 


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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Kazuyo Okamoto
    • 1
  • Ryuichi Iwakiri
    • 1
  • Mitsuru Mori
    • 2
  • Megumi Hara
    • 3
  • Kayoko Oda
    • 1
  • Akiko Danjo
    • 1
  • Akifumi Ootani
    • 1
  • Hiroyuki Sakata
    • 1
  • Kazuma Fujimoto
    • 1
    Email author
  1. 1.Department of Internal MedicineSaga Medical SchoolJapan
  2. 2.Department of Public HealthSapporo Medical University, School of MedicineSapporoJapan
  3. 3.Department of Community Health ScienceSaga Medical SchoolSagaJapan

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