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Chemistry of Natural Compounds

, Volume 40, Issue 3, pp 282–285 | Cite as

Metabolites of the Sea Isolate of Bacteria Streptomyces sp. 6167

  • M. P. Sobolevskaya
  • S. Fotso
  • U. Havash
  • V. A. Denisenko
  • E. Helmke
  • N. G. Prokof'eva
  • T. A. Kuznetsova
  • H. Laatsch
  • G. B. Elyakov
Article

Abstract

Sea isolate of Streptomyces sp. 6167 was found to produce four macrolide antibiotics feigrisolides A, B, and D, and dinactin. The chemical structures of the compounds were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). It was shown that the feigrisolides are cytotoxic to Ehrlich carcinoma tumor cells and to egg-cells of the sea urchin Strongylocentrotus intermedius and antimicrobial to the bacteria Bacillus cereus and Escherichia coli.

marine actinobacteria Streptomyces sp. macrolide antibiotics feigrisolides biological activity 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • M. P. Sobolevskaya
    • 1
  • S. Fotso
    • 2
  • U. Havash
    • 2
  • V. A. Denisenko
    • 2
  • E. Helmke
    • 2
  • N. G. Prokof'eva
    • 1
  • T. A. Kuznetsova
    • 1
  • H. Laatsch
    • 2
  • G. B. Elyakov
    • 1
  1. 1.Pacific Institute of Bioorganic Chemistry, Far-East DivisionRussian Academy of SciencesVladivostok, pr. 100-letiya Vladivostoka, 159, RF
  2. 2.Organic and Biomolecular Chemistry DepartmentHettingen UniversityHettingenGermany

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