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Cancer Causes & Control

, Volume 15, Issue 4, pp 359–365 | Cite as

Coffee, Tea and Caffeine and Risk of Epithelial Ovarian Cancer

  • Susan J. Jordan
  • David M. Purdie
  • Adele C. Green
  • Penelope M. Webb
Article

Abstract

Objective: Studies evaluating the relationships between coffee, tea and caffeine and ovarian cancer risk have given inconsistent results. We have examined these associations using data from an Australian population-based case–control study.

Methods: Women with epithelial ovarian cancer (EOC)(n = 696) and control women selected from the Electoral Roll (n = 786) provided comprehensive reproductive and lifestyle data and completed a food frequency questionnaire.

Results: Increasing coffee consumption was associated with a decreased risk of invasive EOC (p trend = 0.009) with an odds ratio (OR) of 0.51 (95% confidence interval (CI) 0.32–0.80) for consumption of ≥4 cups of coffee per day compared to non-drinkers. The association was significant only for serous and endometrioid/clear cell histological subtypes. There was no association with borderline tumours (OR: 1.20, 95% CI: 0.58–2.47). An inverse relationship was also seen between caffeine intake and EOC but tea consumption was not related to EOC (OR: 1.10 95% CI: 0.76–1.61 for ≥4 cups/day versus none).

Conclusions: As tea contributed significantly to caffeine intake in this population we conclude that the association we observed with coffee is not due to caffeine, but to other components within coffee. We suggest future studies consider the type as well as the amount of each beverage consumed.

caffeine coffee ovarian cancer tea 

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References

  1. 1.
    IARC (1991) Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, IARC, ed. Vol. 51. Lyon.Google Scholar
  2. 2.
    Kuper H, Titus-Ernstoff L, Harlow BL, Cramer DW (2000) Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. Int J Cancer 88: 313–318.PubMedGoogle Scholar
  3. 3.
    Tavani A, Gallus S, Dal Maso L, et al. (2001) Coffee and alcohol intake and risk of ovarian cancer. Nutr Cancer 39: 29–34.PubMedGoogle Scholar
  4. 4.
    Yang CS, Maliakal P, Meng X (2002) Inhibition of carcinogenesis by tea. Ann Rev Pharmacol Toxicol 42: 25–54.Google Scholar
  5. 5.
    Zhang M, Binns CW, Lee AH (2002) Tea consumption and ovarian cancer risk: a case-control study in China. Cancer Epidemiol Biomark Prev 11: 713–718.Google Scholar
  6. 6.
    Purdie D, Green A, Bain C, et al. (1995) Reproductive and other factors and risk of epithelial ovarian cancer: an Australian case-control study. Survey of Women's Health Study Group. Int J Cancer 62: 678–684.PubMedGoogle Scholar
  7. 7.
    Willett WC, Sampson L, Stampfer MJ, et al. (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122: 51–65.PubMedGoogle Scholar
  8. 8.
    Caffeine Survey (1995) Chemistry Centre (WA), Department of Minerals and Energy Western Australia, Health Western Australia: Perth. 1–10.Google Scholar
  9. 9.
    Purdie D, Webb PM, Siskind V, Bain C, Green A (2003) The different etiologies of mucinous and nonmucinous epithelial ovarain cancers. Gynecol Oncol 88: s145–s148.PubMedGoogle Scholar
  10. 10.
    Polychronopoulou A, Tzonou A, Hsieh CC, et al. (1993) Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer. Int J Cancer 55: 402–407.PubMedGoogle Scholar
  11. 11.
    Karakaya SN, El SN, Tas AA (2001) Antioxidant activity of some foods containing phenolic compounds. Int J Food Sci Nutr 52: 501–508.PubMedGoogle Scholar
  12. 12.
    Wu AH, Yu MC, Tseng C-C, Hankin J, Pike M (2003) Green tea and risk of breast cancer in asian americans. Int J Cancer 106: 574–579.PubMedGoogle Scholar
  13. 13.
    Rothman KJ (2002) Epidemiology-An Introduction. Oxford University Press.Google Scholar
  14. 14.
    McLennan W, Podger A (1995) National Nutrition Survey. Foods Eaten, Australia 1995. Canberra: Australian Bureau of Statistics.Google Scholar
  15. 15.
    Byers T, Marshall J, Graham S, Mettlin C, Swanson M (1983) A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71: 681–668.PubMedGoogle Scholar
  16. 16.
    Miller DR, Rosenberg L, Kaufman DW, et al. (1987) Epithelial ovarian cancer and coffee drinking. Int J Epidemiol 16: 13–17.PubMedGoogle Scholar
  17. 17.
    La Vecchia C, Negri E, Franceschi S, D'Avanzo B, Boyle P (1992) Tea consumption and cancer risk. Nutr Cancer 17: 27–31.PubMedGoogle Scholar
  18. 18.
    Zheng W, Doyle T, Kushi LH, et al. (1996) Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women. Am J Epidemiol 144: 175–182.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Susan J. Jordan
    • 1
  • David M. Purdie
    • 1
  • Adele C. Green
    • 1
  • Penelope M. Webb
    • 1
  1. 1.PO Royal Brisbane HospitalQueensland Institute of Medical ResearchAustralia

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