Cancer Causes & Control

, Volume 15, Issue 2, pp 201–209

Alcohol and ovarian cancer risk: results from the Netherlands Cohort Study

  • Leo J. Schouten
  • Maurice P.A. Zeegers
  • R. Alexandra Goldbohm
  • Piet A. van den Brandt
Article

Abstract

Objective: To study alcohol consumption in relation to ovarian cancer risk in a prospective cohort study. Methods: The Netherlands Cohort Study on diet and cancer was initiated in 1986. A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 62,573 postmenopausal women. Follow-up for cancer was established by annual record linkages with the Netherlands Cancer Registry. After 9.3 years of follow-up, 214 incident invasive epithelial ovarian cancer cases and 2211 subcohort members with complete data on alcohol intake were available for analysis. All incidence rate ratios (RRs) were corrected for age, use of oral contraceptives, parity, height, body mass index, energy intake and current cigarette smoking. Results: The RRs of ovarian cancer for women who consumed up to 5, 15 and >15 g of alcohol per day were 1.13 (95% confidence interval, 95% CI = 0.79–1.63), 0.85 (95% CI = 0.53–1.37) and 0.92 (95% CI = 0.55–1.54), respectively, compared to non-drinkers. Alcohol consumption in the form of wine, beer or liquor was not associated with ovarian cancer risk. Conclusion: These data do not suggest a major association between alcohol intake and ovarian cancer risk in this population.

alcohol consumption cohort studies ovarian neoplasms etiology The Netherlands 

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References

  1. 1.
    Alcohol drinking (1988) IARC Working Group, Lyon, 13-20 October 1987. IARC Monogr Eval Carcinog Risks Hum 44: 1-378.Google Scholar
  2. 2.
    World Cancer Research Fund, American Institute for Cancer Research(1997) Food, Nutrition and the Prevention of Cancer: a Global Perspective. Washington DC: World Cancer Research Fund/ American Institute for Cancer Research, pp. 1-670.Google Scholar
  3. 3.
    Gertig D, Hunter D (2002) Ovarian Cancer. In: Adami H-O, Hunter D, Trichopoulos D, eds. Textbook of Cancer Epidemiology, Oxford: Oxford University Press, pp. 378-399.Google Scholar
  4. 4.
    Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ (2001) Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre-and postmenopausal women (United Kingdom). Cancer Causes Control 12: 47-59.Google Scholar
  5. 5.
    Van Thiel DH, Gavaler JS, Lester R (1977) Ethanol: a gonadal toxin in the female. Drug Alcoh Depend 2: 373-380.Google Scholar
  6. 6.
    Fathalla MF (1971) Incessant ovulation-a factor in ovarian neoplasia? Lancet 2: 163.Google Scholar
  7. 7.
    Cramer DW, Welch WR (1983) Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. J Natl Cancer Inst 71: 717-721.Google Scholar
  8. 8.
    Mori M, Harabuchi I, Miyake H, et al. (1988) Reproductive, genetic, and dietary risk factors for ovarian cancer. Am J Epidemiol 128: 771-777.Google Scholar
  9. 9.
    Tavani A, Gallus S, Dal Maso L, et al. (2001) Coffee and alcohol intake and risk of ovarian cancer: an Italian case-control study. Nutr Cancer 39: 29-34.Google Scholar
  10. 10.
    Williams RR, Horm JW (1977) Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. J Natl Cancer Inst 58: 525-547.Google Scholar
  11. 11.
    Hartge P, Schiffman MH, Hoover R, et al. (1989) A case-control study of epithelial ovarian cancer. Am J Obstet Gynecol 161: 10-16.Google Scholar
  12. 12.
    Polychronopoulou A, Tzonou A, Hsieh CC, et al. (1993) Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer. Int J Cancer 55: 402-407.Google Scholar
  13. 13.
    Byers T, Marshall J, Graham S, Mettlin C, Swanson M (1983) A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71: 681-686.Google Scholar
  14. 14.
    Whittemore AS, Wu ML, Paffenbarger RS, Jr, et al. (1988) Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposures to talcum powder, tobacco, alcohol, and coffee. Am J Epidemiol 128: 1228-1240.Google Scholar
  15. 15.
    Kuper H, Titus Ernstoff L, Harlow BL, Cramer DW (2000) Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. Int J Cancer 88: 313-318.Google Scholar
  16. 16.
    Nandakumar A, Anantha N, Dhar M, et al. (1995) A case-control investigation on cancer of the ovary in Bangalore, India. Int J Cancer 63: 361-365.Google Scholar
  17. 17.
    Gwinn ML, Webster LA, Lee NC, Layde PM, Rubin GL (1986) Alcohol consumption and ovarian cancer risk. Am J Epidemiol 123: 759-766.Google Scholar
  18. 18.
    Kato I, Tominaga S, Terao C (1989) Alcohol consumption and cancers of hormone-related organs in females. Jpn J Clin Oncol 19: 202-207.Google Scholar
  19. 19.
    Tzonou A, Day NE, Trichopoulos D, et al. (1984) The epidemiology of ovarian cancer in Greece: a case-control study. Eur J Cancer Clin Oncol 20: 1045-1052.Google Scholar
  20. 20.
    La Vecchia C, Negri E, Franceschi S, et al. (1992) Alcohol and epithelial ovarian cancer. J Clin Epidemiol 45: 1025-1030.Google Scholar
  21. 21.
    Lagiou P, Ye W, Wedren S, et al. (2001) Incidence of ovarian cancer among alcoholic women: a cohort study in Sweden. Int J Cancer 91: 264-266.Google Scholar
  22. 22.
    Kushi LH, Mink PJ, Folsom AR, et al. (1999) Prospective study of diet and ovarian cancer. Am J Epidemiol 149: 21-31.Google Scholar
  23. 23.
    van den Brandt PA, Goldbohm RA, van't Veer P, et al. (1990) A large-scale prospective cohort study on diet and cancer in The Netherlands. J Clin Epidemiol 43: 285-295.Google Scholar
  24. 24.
    van den Brandt PA, Schouten LJ, Goldbohm RA, Dorant E, Hunen PM (1990) Development of a record linkage protocol for use in the Dutch Cancer Registry for Epidemiological Research. Int J Epidemiol 19: 553-558.Google Scholar
  25. 25.
    Goldbohm RA, van den Brandt PA, Dorant E (1994) Estimation of the coverage of Dutch municipalities by cancer registries and PALGA based on hospital discharge data. Tijdschr Soc Gezondheidsz 72: 80-84.Google Scholar
  26. 26.
    Goldbohm RA, van den Brandt PA, Brants HA, et al. (1994) Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur J Clin Nutr 48: 253-265.Google Scholar
  27. 27.
    Goldbohm RA, van't Veer P, van den Brandt PA, et al. (1995) Reproducibility of a food frequency questionnaire and stability of dietary habits determined from five annually repeated measurements. Eur J Clin Nutr 49: 420-429.Google Scholar
  28. 28.
    Stichting NEVO (1986) NEVO-tabel; Nederlands Voedingssto ffenbestand 1986-1987. The Hague: Voorlichtingsbureau voor de Voeding.Google Scholar
  29. 29.
    Weiss NS, Cook LS, Farrow DC, Rosenblatt KA (1996) Ovarian cancer. In: Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention. New York: Oxford University Press, pp. 1040-1057.Google Scholar
  30. 30.
    Schouten LJ, Goldbohm RA, van den Brandt PA (2003) Height, weight, weight change, and ovarian cancer risk in the Netherlands cohort study on diet and cancer. Am J Epidemiol 157: 424-433.Google Scholar
  31. 31.
    Cox Dr (1972) Regression models and life-tables (with discussion). J R Stat Soc Ser B. 34: 187-220.Google Scholar
  32. 32.
    Cleves MA, Gould WW, Gutierrez RG (2002) An Introduction to Survival Analysis Using Stata. Texas: Stata Press, pp. 1-290.Google Scholar
  33. 33.
    Barlow WE (1994) Robust variance estimation for the case-cohort design. Biometrics 50: 1064-1072.Google Scholar
  34. 34.
    Schoenfeld D (1982) Partial residuals for the proportional hazards regression model. Biometrika 69: 239-241.Google Scholar
  35. 35.
    van den Brandt PA, van't Veer P, Goldbohm RA, et al. (1993) A prospective cohort study on dietary fat and the risk of postmenopausal breast cancer. Cancer Res 53: 75-82.Google Scholar
  36. 36.
    Konings EJ, Goldbohm RA, Brants HA, Saris WH, van den Brandt PA (2002) Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study. Cancer 95: 1421-1433.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Leo J. Schouten
    • 1
  • Maurice P.A. Zeegers
    • 1
  • R. Alexandra Goldbohm
    • 2
  • Piet A. van den Brandt
    • 1
  1. 1.Department of EpidemiologyNUTRIM, Maastricht UniversityMaastrichtThe Netherlands
  2. 2.Department of Nutritional EpidemiologyTNO Nutrition and Food Research InstituteZeistThe Netherlands

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