Cancer Causes & Control

, Volume 15, Issue 1, pp 73–82

Adolescent diet and risk of breast cancer

  • A. Lindsay Frazier
  • Lisa Li
  • Eunyong Cho
  • Walter C. Willett
  • Graham A. Colditz


Objectives: To investigate the components of adolescent diet that may influence risk of breast cancer as an adult. Methods: Retrospective cohort study among 47,355 participants in the Nurses Health Study II who answered a 131-item food frequency questionnaire about diet during high school. Cox proportional hazards regression was used to estimate relative risks and 95% confidence intervals among incident cases of breast cancer between 1989 (inception of the study) and 1998 (when high school diet was assessed). Results: Intakes of fat and fiber were not significantly related to risk of breast cancer in multivariate analysis, but increased intake of vegetable fat (Q5versusQ1 multivariate RR = 0.58, 95% CI (0.38–0.86); test for trend p = 0.005) and vitamin E (Q5versusQ1 multivariate RR = 0.61, 95% CI (0.42–0.89); test for trend p = 0.003) were associated with a lower risk. A higher dietary glycemic index (Q5versusQ1 multivariate RR = 1.47, 95% CI (1.04–2.08); test for trend p = 0.01) was associated with increased risk of breast cancer. Conclusions: The apparent protective effects of vegetable fat and vitamin E and adverse effect of high glycemic foods on risk of breast cancer need confirmation in prospective analyses.

adolescence breast cancer diet 


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  1. 1.
    Colditz GA, Frazier AL (1995) Models of breast cancer show that risk is set by events of early life: prevention e.orts must shift focus. Cancer Epidemiol Biomarkers Prev 4(5): 567-571.Google Scholar
  2. 2.
    Schedin PJ, Byers T (1997) Adolescent diet and the risk of breast cancer in adulthood: a role for vitamin A? Nutrition 13(10): 924-925.Google Scholar
  3. 3.
    Marshall WA, Tanner JM (1969) Variations in pattern of pubertal changes in girls. Arch Dis Child 44(235): 291-303.Google Scholar
  4. 4.
    Engelman RW, Day NK, Good RA (1994) Calorie intake during mammary development in.uences cancer risk: lasting inhibition of C3H/HeOu mammary tumorigenesis by peripubertal calorie restriction. Cancer Res 54(21): 5724-5730.Google Scholar
  5. 5.
    Arts CJ, Govers CA, van den Berg H, Thijssen JH (1992) E.ects of wheat bran and energy restriction on onset of puberty, cell proliferation and development of mammary tissue in female rats. Acta Endocrinol (Copenh) 126(5): 451-459.Google Scholar
  6. 6.
    Tretli S, Gaard M (1996) Lifestyle changes during adolescence and risk of breast cancer: an ecologic study of the e.ect of World War II in Norway. Cancer Causes Control 7(5): 507-512.Google Scholar
  7. 7.
    Nilsen TI, Vatten LJ (2001) Adult height and risk of breast cancer: a possible e.ect of early nutrition. Br J Cancer 85(7): 959-961.Google Scholar
  8. 8.
    Buell P (1973) Changing incidence of breast cancer in Japanese-American women. J Natl Cancer Inst 51(5): 1479-1483.Google Scholar
  9. 9.
    Ziegler RG, Hoover RN, Pike MC, et al. (1993) Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 85(22): 1819-1827.Google Scholar
  10. 10.
    Russo J, Tay LK, Russo IH (1982) Di.erentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2(1): 5-73.Google Scholar
  11. 11.
    Russo J, Russo IH (1987) Biological and molecular basis of mammary carcinogenesis. Lab Invest 57(2): 112-137.Google Scholar
  12. 12.
    Tokunaga M, Land CE, Tokuoka S, Nishimori I, Soda M, Akiba S (1994) Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiat Res 138(2): 209-223.Google Scholar
  13. 13.
    Schernhammer ES, Hankinson SE (2003) Epidemiologic approaches to evaluating IGF and cancer risk. In: LeRoith D, Zumkeller W, Baxter R, eds. Insulin-like Growth Factors: Landes Bioscience. Chapter 19. 2003, pp. 317-338.Google Scholar
  14. 14.
    Apter D (1996) Hormonal events during female puberty in relation to breast cancer risk. Eur J Cancer Prev 5(6): 476-482.Google Scholar
  15. 15.
    Willett WC (2001) Diet and breast cancer. J Intern Med 249(5): 395-411.Google Scholar
  16. 16.
    Willett WC (1998) Nutritional Epidemiology, 2nd edn. New York: Oxford University Press.Google Scholar
  17. 17.
    Frazier AL, Willett WC, Colditz GA (1995) Reproducibility of recall of adolescent diet: Nurses' Health Study (United States). Cancer Causes Control 6(6): 499-506.Google Scholar
  18. 18.
    Department of Agriculture ARS(2001) USDA Nutrient Database for Standard Reference, xxRelease 14, SR14.Google Scholar
  19. 19.
    Holland G, Welch AA, Unwin ID, Buss DH, Paul AA, Dat S (1991) The Composition of Foods, 5th edn. Cambridge (UK): The Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food.Google Scholar
  20. 20.
    Dial S, Eitenmiller R (1995) Tocopherols and Tocotrienols in Key Foods in the US Diet. AOCS Press, pp. 327-342.Google Scholar
  21. 21.
    Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124(1): 17-27.Google Scholar
  22. 22.
    Jenkins DJ, Wolever TM, Taylor RH, et al. (1981) Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34(3): 362-366.Google Scholar
  23. 23.
    Adams C (1975) Nutritive Values of American Foods. Handbook no. 456, Washington DC: US Department of Agriculture (USDA).Google Scholar
  24. 24.
    Wolever TM (1990) The glycemic index. World Rev Nutr Diet 62: 120-185.Google Scholar
  25. 25.
    Wolever TM, Nguyen PM, Chiasson JL, et al. (1994) Determinants of diet glycemic index calculated retrospectively from diet records of 342 individuals with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 59(6): 1265-1269.Google Scholar
  26. 26.
    Kleinbaum D (1988) Applied Regression Analysis and Other Multivariable Methods. Boston: PWS-Kent, pp. 102-123.Google Scholar
  27. 27.
    Cho E, Spiegelman D, Hunter DJ, et al. (2003) Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 95(14): 1079-1085.Google Scholar
  28. 28.
    Hislop TG, Coldman AJ, Elwood JM, Brauer G, Kan L (1986) Childhood and recent eating patterns and risk of breast cancer. Cancer Detect Prev 9(1-2): 47-58.Google Scholar
  29. 29.
    Frazier AL, Ryan CT, Rockett H, Willett WC, Colditz GA (2003) Adolescent diet and risk of breast cancer. Breast Cancer Res 5(2): R59-R64.Google Scholar
  30. 30.
    Negri E, La Vecchia C, Franceschi S, et al. (1996) Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 65(2): 140-144.Google Scholar
  31. 31.
    Levi F, Pasche C, Lucchini F, La Vecchia C (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91(2): 260-263.Google Scholar
  32. 32.
    Malafa MP, Neitzel LT (2000) Vitamin E succinate promotes breast cancer tumor dormancy. J Surg Res 93(1): 163-170.Google Scholar
  33. 33.
    Kline K, Yu W, Sanders B (1998) Vitamin E: Mechanisms of Action as Tumor Cell Growth Inhibitors. Washington, DC: IOS Press.Google Scholar
  34. 34.
    Augustin LS, Dal Maso L, La Vecchia C, et al. (2001) Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Ann Oncol 12(11): 1533-1538.Google Scholar
  35. 35.
    Franceschi S, Favero A, Decarli A, et al. (1996) Intake of macronutrients and risk of breast cancer. Lancet 347(9012): 1351-1356.Google Scholar
  36. 36.
    Franceschi S, Dal Maso L, Augustin L, et al. (2001) Dietary glycemic load and colorectal cancer risk. Ann Oncol 12(2): 173-178.Google Scholar
  37. 37.
    Michaud DS, Liu S, Giovannucci E, Willett WC, Colditz GA, Fuchs CS (2002) Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study. J Natl Cancer Inst 94(17): 1293-1300.Google Scholar
  38. 38.
    Pollak M (2000) Insulin-like growth factor physiology and cancer risk. Eur J Cancer 36(10): 1224-1228.Google Scholar
  39. 39.
    Pryor M, Slattery ML, Robison LM, Egger M (1989) Adolescent diet and breast cancer in Utah. Cancer Res 49(8): 2161-2167.Google Scholar
  40. 40.
    Potischman N, Weiss HA, Swanson CA, et al. (1998) Diet during adolescence and risk of breast cancer among young women. J Natl Cancer Inst 90(3): 226-233.Google Scholar
  41. 41.
    Shu XO, Jin F, Dai Q, et al. (2001) Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 10(5): 483-488.Google Scholar
  42. 42.
    Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC (2002) Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 23(9): 1491-1496.Google Scholar
  43. 43.
    Friedenreich CM, Slimani N, Riboli E (1992) Measurement of past diet: review of previous and proposed methods. Epidemiol Rev 14: 177-196.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • A. Lindsay Frazier
    • 1
    • 2
  • Lisa Li
    • 2
  • Eunyong Cho
    • 2
  • Walter C. Willett
    • 2
    • 3
    • 4
  • Graham A. Colditz
    • 2
    • 4
  1. 1.Division of Pediatric OncologyDana-Farber Cancer Institute, Harvard Medical SchoolUSA
  2. 2.Channing LaboratoryBostonUSA
  3. 3.Department of NutritionHarvard School of Public HealthUSA
  4. 4.Department of EpidemiologyHarvard School of Public HealthUSA

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