Breast Cancer Research and Treatment

, Volume 85, Issue 1, pp 23–29 | Cite as

A Comparison of the Biological and Clinical Features of Invasive Lobular and Ductal Carcinomas of the Breast

  • T. Korhonen
  • H. Huhtala
  • K. Holli


Altogether 295 consecutive pure lobular invasive breast cancers diagnosed between 1990 and 1999 in the area of Tampere University Hospital were compared to 295 ductal invasive breast cancers. Biological factors, DFS, OS, recurrence types, survival after recurrence and other primary cancers were analyzed. ILC tumors were more often hormone receptor-positive, slowly proliferative and Erbb-2-negative. During the mean follow-up time of 5.1 years 76 recurrences in both groups were discovered. During the whole follow-up time there was more metastation to gynecological organs and GI tract in the ILC group. Bilateral breast cancers did not differ between the groups. DFS and OS were the same between the groups despite the fact that ILC patients received statistically significantly less adjuvant treatment. In conclusion, since ILC cancers are more often hormone receptor-positive, there is a good option to adjuvant endocrine therapy with present and future preparations, this possibly leading to improvement in OS.

biology breast cancer ductal lobular recurrence 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Corea P, Johnson WD: International variation in the histology of breast carcinoma. UICC Tech Rep Ser 35: 36–65, 1978Google Scholar
  2. 2.
    Martinez VM, Azzopardi JG: Invasive lobular carcinoma of the breast: incidence and variants. Histopathology 3: 467–488, 1979Google Scholar
  3. 3.
    Berg JW, Hutter RVP: Breast Cancer. Cancer Suppl 75: 257–269, 1995Google Scholar
  4. 4.
    Toikkanen S, Pylkkänen L, Joensuu H: Invasive lobular carcinoma of the breast has better short-and long-term survival than invasive ductal carcinoma. Br J Cancer 76: 1234–1240, 1997Google Scholar
  5. 5.
    Dixon AR, Ellis IO, Elston CW, Blamey RW: A comparison of the clinical metastatic patterns of invasive lobular and ductal carcinomas of the breast. Br J Cancer 63: 634–635, 1991Google Scholar
  6. 6.
    Sastre-Garau X, Jouve M, Asselain B, Vincent-Salomon A, Beuzeboc P, Dorval T, Durand J, Fourquet A, Pouillart P: yIn-filtrating lobular carcinoma of the breast. Clinicopathological analysis of 975 cases with references to data on conservative therapy and metastatic patterns. Cancer 77: 113–120, 1996Google Scholar
  7. 7.
    Harris M, Howell A, Crissohou M, Swindell RIC, Hudson M, Sellwood RA: A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer 50: 23–30, 1984Google Scholar
  8. 8.
    Lamovec J, Bracko M:Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol 48: 28–33, 1991Google Scholar
  9. 9.
    Borst MJ, Ingold JA: Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery 114 637–642, 1993Google Scholar
  10. 10.
    du Toit RS, Locker AP, Ellis IO, Elston CW, Nicholson RI, Robertson JFR, Blamey RW: An evaluation of difference in prognosis, recurrence patterns and receptor status between invasive lobular and other invasive carcinomas of the breast. Eur J Surg Oncol 17: 251–257, 1991Google Scholar
  11. 11.
    Silverstein MJ, Lewinsky BS, Waisman JR, Gierson ED, Colburn WJ, Senofsky GM, Gamagami P: Infiltrating lobular carcinoma. Is it different from infiltrating ductal carcinoma? Cancer 73: 1673–1677, 1992Google Scholar
  12. 12.
    Fechner RE: Infiltrating lobular carcinoma without lobular carcinoma in situ. Cancer 29: 1539–1545, 1972Google Scholar
  13. 13.
    Fondrinier E, Guerin O, Lorimier G: A comparison of metastatic patterns of invasive ductal and lobular carcinomas of the breast: result of a matched study. Bull Cancer 84: 1101–1107, 1997Google Scholar
  14. 14.
    Smith B, Howell A, Wagstaff J: Infiltrating lobular carcinoma of the breast: response to endocrine therapy and survival. Eur J Cancer Clin Oncol 23: 979–982, 1987Google Scholar
  15. 15.
    Bumbers HL, Hasset JM, Penetrante RB, Hoover EL, Holyoke ED: Endocrine organ metastases in subjects with lobular carcinomas of the breast. Arch Surg 128: 1344–1347, 1993Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • T. Korhonen
    • 1
  • H. Huhtala
    • 2
  • K. Holli
    • 1
  1. 1.Department of Palliative MedicineTampere University Hospital, and School of MedicineTampereFinland
  2. 2.School of Public HealthUniversity of TampereTampereFinland

Personalised recommendations