Breast Cancer Research and Treatment

, Volume 84, Issue 2, pp 85–97 | Cite as

Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer

  • Stephen A. Boppart
  • Wei Luo
  • Daniel L. Marks
  • Keith W. Singletary
Article

Abstract

Diagnostic trends in medicine are being directed toward cellular and molecular processes, where treatment regimens are more amenable for cure. Optical imaging is capable of performing cellular and molecular imaging using the short wavelengths and spectroscopic properties of light. Diffuse optical tomography is an optical imaging technique that has been pursued as an alternative to X-ray mammography. While this technique permits non-invasive optical imaging of the whole breast, to date it is incapable of resolving features at the cellular level. Optical coherence tomography (OCT) is an emerging high-resolution biomedical imaging technology that for larger and undifferentiated cells can perform cellular-level imaging at the expense of imaging depth. OCT performs optical ranging in tissue and is analogous to ultrasound except reflections of near-infrared light are detected rather than sound. In this paper, an overview of the OCT technology is provided, followed by images demonstrating the feasibility of using OCT to image cellular features indicative of breast cancer. OCT images of a well-established carcinogen-induced rat mammary tumor model were acquired. Images from this common experimental model show strong correlation with corresponding histopathology. These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer.

breast cancer imaging image-guided surgery MNU-induced carcinogenesis optical coherence tomography optical imaging rat mammary tumor 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Stephen A. Boppart
    • 1
  • Wei Luo
    • 2
  • Daniel L. Marks
    • 2
  • Keith W. Singletary
    • 3
  1. 1.Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of MedicineUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  2. 2.Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  3. 3.Department of Food Science and Human Nutrition, Functional Foods for Health ProgramUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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