Is Male Breast Cancer Similar or Different than Female Breast Cancer?
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Objective. To determine if male breast carcinogenesis was similar to its more common female counterpart, we compared incidence patterns among men and women with breast cancer.
Methods. Breast cancer records were obtained from the SEER database. Women were stratified by age <50 and ≥50 years to simulate premenopausal and postmenopausal breast cancer.
Results. Age-adjusted incidence trends were stable among men but increased among women. Male to female breast cancer ratio was higher for blacks than for whites. Favorable prognostic factors reflective of tumor biology (nuclear grade and hormone receptor expression) were more common for men and postmenopausal women than for premenopausal women. For example, low nuclear grade, estrogen and progesterone receptor-positive expression were more common among men and postmenopausal women than among premenopausal women. The age-specific incidence rate curve for men increased steadily for all ages with a constant slope. On the other hand, age-specific rates for women increased rapidly until age 50 years then rose at a slower rate for postmenopausal women. Age-frequency distribution for male breast cancer was unimodal, with peak incidence at age 71 years. Age-frequency distribution for women was bimodal with early-onset and late-onset incidence at 52 and 71 years, respectively.
Conclusions. Gender-specific incidence trends differed, most likely reflective of female-related changes in surveillance and/or reproductive risk factors. On the other hand, similar prognostic factor profiles reflective of tumor biology, age-specific incidence rate patterns, and age-frequency distributions suggested that male breast cancer was more like postmenopausal than premenopausal female breast cancer.
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- 1.Jemal A, Murray T, Samuels A et al.: Cancer statistics, 2003. CA Cancer J Clin 53: 5–26, 2003Google Scholar
- 2.Moolgavkar SH, Lee JA, Hade RD: Comparison of age-specific mortality from breast cancer in males in the United States and Japan. J Natl Cancer Inst 60: 1223–1225, 1978Google Scholar
- 3.Parkin DM, Bray FI, Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 37(Suppl 8): S4–S66, 2001Google Scholar
- 4.Levi F, Lucchini F, La Vecchia C: Epidemiology of male breast cancer. Eur J Cancer Prev 11: 315–318, 2002Google Scholar
- 5.Ewertz M, Holmberg L, Karjalainen S et al.: Incidence of male breast cancer in Scandinavia, 1943-1982. Int J Cancer 43: 27–31, 1989Google Scholar
- 6.Thomas DB: Breast cancer in men. Epidemiol Rev 15: 220–231, 1993Google Scholar
- 7.Clemmesen J: Carcinoma of the breast. Br J Radiol 21: 583–590, 1948Google Scholar
- 8.Yasui Y, Potter JD: The shape of age-incidence curves of female breast cancer by hormone-receptor status. Cancer Causes Contr 10: 431–437, 1999Google Scholar
- 9.Tarone RE, Chu KC: The greater impact of menopause on ER-than ER+ breast cancer incidence: a possible explanation (United States). Cancer Causes Contr 13: 7–14, 2002Google Scholar
- 10.Anderson WF, Chatterjee N, Ershler WB et al.: Estrogen receptor breast cancer phenotypes in the surveillance, epidemiology, and end results database. Breast Cancer Res Treat 76: 27–36, 2002Google Scholar
- 11.SEER, 2003Google Scholar
- 12.Percy C, Holten VV, Muir C: International Classification of Diseases for Oncology. World Health Organization, Geneva, 1990Google Scholar
- 13.Armitage P, Doll R: The age distribution of cancer and a multistage theory of carcinogenesis. Br J Cancer 8: 1–12, 1954Google Scholar
- 14.Anderson WF, Chu KC, Chatterjee N et al.: Tumor variants by hormone receptor expression in white patients with node-negative breast cancer from the Surveillance, Epidemiology, and End Results database. J Clin Oncol 19: 18–27, 2001Google Scholar
- 15.von Pirquet C: Allergie des Lebensalters, die bosartigen Geschwulste ('Allergy of age, the Malignant Tumors'). Thieme Verlag, Leipzig, Germany, 1930Google Scholar
- 16.Brunet M, Hucher M, Boutros F et al.: [Is there any bimodality of the age distribution of male mammary cancer (author's transl)?]. Rev Epidemiol Sante Publique 24: 405–413, 1976Google Scholar
- 17.Sasco AJ, Lowenfels AB, Pasker-de Jong P: Review article: epidemiology of male breast cancer. A meta-analysis of published case-control studies and discussion of selected aetiological factors. Int J Cancer 53: 538–549, 1993Google Scholar
- 18.Amir H, Makwaya CK, Moshiro C et al.: Carcinoma of the male breast: a sexually transmitted disease? East Afr Med J 73: 187–190, 1996Google Scholar
- 19.Brinton LA, Benichou J, Gammon MD et al.: Ethnicity and variation in breast cancer incidence. Int J Cancer 73: 349–355, 1997Google Scholar
- 20.Hankey BF, Miller B, Curtis R et al.: Trends in breast cancer in younger women in contrast to older women. J Nat Cancer Inst Monogr 16: 7–14, 1994Google Scholar
- 21.Chen VW, Correa P, Kurman RJ et al.: Histological characteristics of breast carcinoma in blacks and whites. Cancer Epidemiol Biomarkers Prev 3: 127–135, 1994Google Scholar
- 22.Eley JW, Hill HA, Chen VW et al.: Racial differences in survival from breast cancer. Results of the national cancer institute black/white cancer survival study. JAMA 272: 947–954, 1994Google Scholar
- 23.Henson DE, Chu KC, Levine PH: Histologic grade, stage, and survival in breast carcinoma: comparison of African American and Caucasian women. Cancer 98: 908–917, 2003Google Scholar
- 24.Pike MC, Krailo MD, Henderson BE et al.: ‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer. Nature 303: 767–770, 1983Google Scholar
- 25.Keller AZ: Demographic, clinical and survivorship characteristics of males with primary cancer of the breast. Am J Epidemiol 85: 183–199, 1967Google Scholar
- 26.Hsing AW, McLaughlin JK, Cocco P et al.: Risk factors for male breast cancer (United States). Cancer Causes Contr 9: 269–275, 1998Google Scholar
- 27.Rose DP: Endocrine epidemiology of male breast cancer (review). Anticancer Res 8: 845–850, 1988Google Scholar
- 28.Everson RB, Li FP, Fraumeni Jr JF et al.: Familial male breast cancer. Lancet 1: 9–12, 1976Google Scholar
- 29.Wooster R, Neuhausen SL, Mangion J et al.: Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 265: 2088–2090, 1994Google Scholar
- 30.Stratton MR, Ford D, Neuhasen S et al.: Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q. Nat Genet 7: 103–107, 1994Google Scholar
- 31.Thorlacius S, Tryggvadottir L, Olafsdottir GH et al.: Linkage to BRCA2 region in hereditary male breast cancer. Lancet 346: 544–545, 1995Google Scholar
- 32.Mabuchi K, Bross DS, Kessler II: Risk factors for male breast cancer. J Natl Cancer Inst 74:371–375, 1985Google Scholar
- 33.Narod SA: Modifiers of risk of hereditary breast and ovarian cancer. Nature Rev Cancer 2: 113–123, 2002Google Scholar
- 34.Hamilton AS, Mack TM: Puberty and genetic susceptibility to breast cancer in a case-control study in twins. N Engl J Med 348: 2313–2322, 2003Google Scholar