Biochemistry (Moscow)

, Volume 69, Issue 7, pp 738–741 | Cite as

Mechanisms of Neuroprotective Action of Vitamin D3

  • A. V. Kalueff
  • K. O. Eremin
  • P. Tuohimaa


This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D3, in the nervous system.

vitamin D3 calcitriol nervous system neuroprotection 


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  1. 1.
    Ahonen, M. (2002) Acta Univers. Tamperens., 885, 1–101.Google Scholar
  2. 2.
    Garcion, E., Nataf, S., Berod, A., Darcy, F., and Brachet, P. (1997) Brain Res. Mol. Brain Res., 45, 255–267.PubMedGoogle Scholar
  3. 3.
    Garcion, E., Wion_Barbot, N., Montero_Menei, C. N., Berger, F., and Wion, D. (2002) Tr. Endocrinol. Metab., 13, 100–105.CrossRefGoogle Scholar
  4. 4.
    Eyles, D., Brown, J., Mackay_Sim, A., McGrath, J., and Feron, F. (2003) Neurosci., 118, 641–653.CrossRefGoogle Scholar
  5. 5.
    Norman, A. W., Ishizuka, S., and Okamura, W. H. (2001) J. Steroid Biochem. Mol. Biol., 76, 49–59.CrossRefPubMedGoogle Scholar
  6. 6.
    St_Arnaud, R. (1999) Bone, 25, 127–129.CrossRefPubMedGoogle Scholar
  7. 7.
    Sanchez, B., Lopez_Martin, E., Segura, C., Labandeira_ Garcia, J. L., and Perez_Fernandez, R. (2002) Brain Res. Mol. Brain Res., 108, 143–146.PubMedGoogle Scholar
  8. 8.
    Shinpo, K., Kikuchi, S., Sasaki, H., Moriwaka, F., and Tashiro, K. (2000) J. Neurosci. Res., 62, 374–382.CrossRefPubMedGoogle Scholar
  9. 9.
    McLeod, J. F., and Cooke, N. E. (1989)J. Biol. Chem., 264, 21760–21769.PubMedGoogle Scholar
  10. 10.
    Kamei, Y., Kawada, T., Fukuwatori, T., Ono, T., Kato, S., and Sugimoto, E. (1995) Gene, 152, 281–282.CrossRefPubMedGoogle Scholar
  11. 11.
    Losel, R., and Wehling, M. (2003) Nature Rev. Mol. Cell Biol., 4, 46–55.CrossRefGoogle Scholar
  12. 12.
    Brown, A. J., Dusso, A., and Slatopolsky, E. (1999)Am. J. Physiol., 277, 157–175.Google Scholar
  13. 13.
    Wang, Y., Chiang, Y. H., Su, T. P., Hayashi, T., Morales, M., Hoffer, B. J., and Lin, S. Z. (2000) NeuroPharmacol., 39, 873–880.CrossRefGoogle Scholar
  14. 14.
    Losel, R., and Wehling, M. (2003) J. Steroid Biochem. Mol. Biol., 83, 167–171.CrossRefGoogle Scholar
  15. 15.
    Wali, R. K., Kong, J., Sitrin, M. D., Bisonette, M., and Li, Y. C. (2003) J. Cell Biochem., 88, 794–801.CrossRefPubMedGoogle Scholar
  16. 16.
    Capiati, D., Benassati, S., and Boland, R. L. (2002) J. Cell Biochem., 86, 128–135.CrossRefPubMedGoogle Scholar
  17. 17.
    Boyan, B. D., Bonewald, L. F., Sylvia, V. L., Nemere, I., Larsson, D., Norman, A. W., Rosser, J., Dean, D. D., and Schwartz, Z. (2002) Steroids, 67, 421–427.CrossRefPubMedGoogle Scholar
  18. 18.
    Erben, R. G., Soegiarto, D. W., Weber, K., Zeitz, U., Lieberherr, M., Gniadecki, R., Moller, G., Adamski, J., and Balling, R. (2002) Mol. Endocrinol., 16, 1524–1537.CrossRefPubMedGoogle Scholar
  19. 19.
    Garcion, E., S indji, L., Nataf, S., Brachet, P., Darcy, F., and Montero_Menei, C. N. (2003) Acta Neuropathol., 105, 438–448.PubMedGoogle Scholar
  20. 20.
    Langub, M. C., Herman, J. P., Malluche, H. H., and Koszewski, N. J. (2001) Neurosci., 104, 49–56.CrossRefGoogle Scholar
  21. 21.
    Baas, D., Prüfer, K., Ittel, M. E., Kuchler_Bopp, S., Labourdette, G., Sarlieve, L. L., and Brachet, P. (2000) Glia, 31, 59–68.CrossRefPubMedGoogle Scholar
  22. 22.
    Cornet, A., Baudet, C., Neveu, I., Baron_Van Evercooren, A., Brachet, P., and Naveilhan, P. (1999) J. Neurosci. Res., 53, 742–746.CrossRefGoogle Scholar
  23. 23.
    Prüfer, K., Veenstra, T. D., Jirikowski, G. F., and Kumar, R. (1999) J. Chem. Neuroanat., 16, 135–145.CrossRefPubMedGoogle Scholar
  24. 24.
    Walbert, T., Jirikowski, G. F., and Prufer, K. (2001) Horm. Metab. Res., 33, 525–531.CrossRefPubMedGoogle Scholar
  25. 25.
    Jia, Z., and Nimere, I. (1999) Steroids, 64, 541–550.CrossRefPubMedGoogle Scholar
  26. 26.
    Zehnder, D., Bland, R., Williams, M. C., McNinch, R. W., Howie, A. J., Stewart, P. M., and Hewison, M. (2001) J. Clin. Endocrinol. Metab., 86, 888–894.CrossRefPubMedGoogle Scholar
  27. 27.
    Brewer, L. D., Thibault, V., Chen, K. C., Langub, M. C., Landfield, P. W., and Porter, N. M. (2001) J. Neurosci., 21, 98–108.PubMedGoogle Scholar
  28. 28.
    Brown, J., Bianco, J. I., McGrath, J. J., and Eyles, D. W. (2003) Neurosci. Lett., 343, 139–143.CrossRefPubMedGoogle Scholar
  29. 29.
    Ibi, M., Sawada, H., Nakanishi, M., Kume, T., Katsuki, H., Kaneko, S., Shimohama, S., and Akaike, A. (2001) Neuropharmacol., 40, 761–771.CrossRefGoogle Scholar
  30. 30.
    Li, Y. C., Pirro, A. E., and Demay, M. B. (1998) Endocrinol., 139, 847–851.CrossRefGoogle Scholar
  31. 31.
    Sutherland, M. K., Somerville, M. J., Yoong, L. K., Bergeron, C., Haussler, M. R., and McLachlan, D. R. (1992) Brain Res. Mol. Brain Res., 13, 239–250.PubMedGoogle Scholar
  32. 32.
    Chen, K. B., Lin, A. M., and Chiu, T. H. (2003) Ann. N. Y. Acad. Sci., 993, 313–324.PubMedGoogle Scholar
  33. 33.
    Lin, A. M., Fan, S. F., Yang, D. M., Hsu, L. L., and Yang, C. H. (2003) Free Rad. Biol. Med., 34, 1416–1425.CrossRefPubMedGoogle Scholar
  34. 34.
    Wang, J. Y., Wu, J. N., Cherng, T. L., Hoffer, B. J., Chen, H. H., Borlongan, C. V., and Wang, Y. (2001) Brain Res., 904, 67–75.CrossRefPubMedGoogle Scholar
  35. 35.
    Chaterjee, M. (2001) Mutat. Res., 475, 69–88.PubMedGoogle Scholar
  36. 36.
    Kroncke, K. D., Klotz, L. O., Suschek, C. V., and Sies, H. (2002) J. Biol. Chem., 277, 13294–13301.CrossRefPubMedGoogle Scholar
  37. 37.
    Neveu, I., Naveilhan, P., Jehan, F., Baudet, C., Wion, D., De Luca, H. F., and Brachet, P. (1994) Brain Res. Mol. Brain Res., 24, 70–76.PubMedGoogle Scholar
  38. 38.
    Neveu, I., Naveilhan, P., Menaa, C., Wion, D., Brachet, P., and Garabedian, M. (1994) J. Neurosci. Res., 38, 214–220.PubMedGoogle Scholar
  39. 39.
    Bemiss, C. J., Mahon, B. D., Henry, A., Weaver, V., and Cantorna, M. T. (2002) Arch. Biochem. Biophys., 402, 249–254.CrossRefPubMedGoogle Scholar
  40. 40.
    Meehan, T. F., and DeLuca, H. F. (2002) Arch. Biochem. Biophys., 408, 200–204.CrossRefPubMedGoogle Scholar
  41. 41.
    Canthorna, M. T., Hayes, C. E., and DeLuca, H. F. (1996) Proc. Natl. Acad. Sci. USA, 93, 7861–7864.CrossRefPubMedGoogle Scholar
  42. 42.
    Canthorna, M. T., Woodward, W. D., Hayes, C. E., and DeLuca, H. F. (1998) J. Immunol., 160, 5314–5319.PubMedGoogle Scholar
  43. 43.
    D'Hellencourt, C. L., Montero_Menei, C. N., Bernard, R., and Couez, D. (2003) J. Neurosci. Res., 71, 575–582.CrossRefPubMedGoogle Scholar
  44. 44.
    Rotkiewicz, P., Sicinska, W., Kolinski, A., and DeLuca, H. F. (2001) Proteins, 44, 188–199.CrossRefPubMedGoogle Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2004

Authors and Affiliations

  • A. V. Kalueff
    • 1
    • 4
  • K. O. Eremin
    • 2
    • 3
  • P. Tuohimaa
    • 3
  1. 1.KievUkraine
  2. 2.Institute of PharmacologyRussian Academy of Medical Sciences, ul. Baltiiskaya 8MoscowRussia
  3. 3.Department of Clinical Chemistry, Medical SchoolUniversity of TampereTampereFinland
  4. 4.Medical School, University of TampereTampereFinland

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