Effect of Peptide Pro-Gly-Pro on Stress-Induced Behavioral Changes in Rats

  • G. N. Kopylova
  • S. E. Badmaeva
  • N. G. Levitskaya
  • G. E. Samonina
  • B. A. Umarova
  • A. A. Guseva
Article

Abstract

Tripeptide PGP in a dose of 1 mg/kg had a correcting effect on behavioral disorders in rats induced by stress exposure (forced swimming). PGP prevented the increase in anxiety and decrease in orientation and exploratory activity. Our results suggest that the effect of this peptide is realized via central nervous structures involved in organism's response to stress factors.

stress behavior regulatory peptides 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • G. N. Kopylova
    • 1
  • S. E. Badmaeva
    • 1
  • N. G. Levitskaya
    • 1
  • G. E. Samonina
    • 1
  • B. A. Umarova
    • 1
  • A. A. Guseva
    • 1
  1. 1.Department of Human and Animal Physiology, Biological FacultyM. V. Lomonosov Moscow State University.Moscow

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