Abstract
Daily treatment of outbred albino mice with gammafos in radioprotective doses of 300 and 500 mg/kg for 4 days produced a cumulative toxic effect. This effect was not observed after decreasing the dose of gammafos to 100 mg/kg. Repeated peroral administration of melatonin and ascorbic acid in a dose of 200 mg/kg 30 min before treatment with gammafos reduced its cumulative toxic effect. Succinic acid in a dose of 100 mg/kg was ineffective under these conditions. The cumulative death time for 50% animals receiving gammafos alone or in combination with melatonin, ascorbic acid, and succinic acid was 3.08, 4.29, 4.06, and 2.97 days, respectively.
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Vasin, M.V., Ushakov, I.B., Kovtun, V.Y. et al. Effect of Melatonin, Ascorbic Acid, and Succinic Acid on the Cumulative Toxic Effect of Repeated Treatment with Gammafos (Amifostine). Bulletin of Experimental Biology and Medicine 137, 450–452 (2004). https://doi.org/10.1023/B:BEBM.0000038150.18659.3b
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DOI: https://doi.org/10.1023/B:BEBM.0000038150.18659.3b