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Bulletin of Experimental Biology and Medicine

, Volume 137, Issue 2, pp 139–142 | Cite as

Free Radical Processes in the Liver of Adult and Old Rats during Stress

  • V. V. Davydov
  • I. V. Zakharchenko
  • V. G. Ovsyannikov
Article

Abstract

We measured the content of free radical lipid peroxidation products, intensity of induced lipid peroxidation, and concentration of carbonylated proteins in the liver of adult (10-12 months) and old rats (22-25 months) subjected to 30-min immobilization. Changes in the intensity of induced lipid peroxidation in homogenates and accumulation of carbonylated proteins in subcellular liver fractions indicate that immobilization stimulates free radical generation in the liver of both adult and old rats. The intensity of this process in old rats surpassed that in adult animals.

oxidative stress immobilization aging liver 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • V. V. Davydov
    • 1
    • 2
  • I. V. Zakharchenko
    • 1
    • 2
  • V. G. Ovsyannikov
    • 1
    • 2
  1. 1.Laboratory of Age-Specific Endocrinology and Metabolism, Institute for Child and Adolescent WelfareAcademy of Medical SciencesKharkov
  2. 2.Department of PathophysiologyRostov State Medical UniversityRostov

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