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Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 5, pp 494–498 | Cite as

Role of Matrix Metalloproteinases 2 and 9 in Determination of Invasive Potential of Pancreatic Tumors

  • L. E. Gurevich
Article

Abstract

Our findings indicate that expression of matrix metalloproteinase-2 is an important prognostic marker of invasive potential of pancreatic tumors. Expression of this marker in neuroendocrine tumors (particularly in gastrinomas) can be used as a differential diagnostic criterion characterizing more malignant phenotype of tumors with the presence of ductal component. On the contrary, weak expression matrix metalloproteinase-9 is characteristic of less invasive phenotype of tumor cells (neuroendocrine and solid pseudopapillary tumors, mucinous cystadenomas). Co-expression of matrix metalloproteinases 2 and 9 is an unfavorable prognostic sign.

metalloproteinases pancreatic tumors invasive properties cell-to-cell interactions extracellular matrix destruction 

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REFERENCES

  1. 1.
    S. R. Bramhall, J. P. Neoptolemos, G. W. H. Stamp, et al., J. Pathol., 182, 347-355 (1997).Google Scholar
  2. 2.
    Z. S. Galis, M. Muszynski, G. K. Sukhova, et al., Circ. Res., 75, 181-189 (1994).Google Scholar
  3. 3.
    G. Gianelli, J. Falk-Marziller, O. Schiradi, et al., Science, 277, 225-228 (1997).Google Scholar
  4. 4.
    A. John and G. Tuszynski, Pathol. Oncol. Res., 7, No. 1, 14-23 (2001).Google Scholar
  5. 5.
    N. Kawano, H. Osawa, I. Takaaki, et al., Hum. Pathol., 28, 613-622 (1997).Google Scholar
  6. 6.
    S. K. Kim and M. Hebrok, Genes Dev., 15, 111-127 (2001).Google Scholar
  7. 7.
    W. J. Lamoreaux, M. E. Fitzgerald, A. Reiner, et al., Microvasc. Res., 55, 29-42 (1998).Google Scholar
  8. 8.
    M. Lorh, B. Trautmann, S. Peters, et al., Pancreas, 12, 248-259 (1996).Google Scholar
  9. 9.
    Sh.-T. Shi, R. J. Cote, and C. R. Taylor, J. Histochem. Cytochem., 45, 327-343 (1997).Google Scholar
  10. 10.
    L. A. Sternberger, Immunocytochemistry, New York (1979).Google Scholar
  11. 11.
    W. G. Stetler-Stevenson, Am. J. Pathol., 148, 1345-1351 (1996).Google Scholar
  12. 12.
    A. Talvensari-Matila, P. Paakko, M. Hoyhtya, et al., Cancer, 83, 1153-1162 (1998).Google Scholar
  13. 13.
    G. Taraboletti, S. D'Ascerzo, P. Borsotti, et al., Am. J. Pathol., 160, 673-680 (2002).Google Scholar
  14. 14.
    Z.-H. Wang, T. Manabe, G. Ohshio, et al., Pancreas, 9, 758-763 (1994).Google Scholar
  15. 15.
    Z. Werb, Cell, 91, 439-442 (1997).Google Scholar

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • L. E. Gurevich
    • 1
    • 2
  1. 1.M. F. Vladimirskii Moscow Regional Research and Clinical InstituteMoscow
  2. 2.Russian Academy of Medical SciencesInstitute of Human MorphologyMoscow

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