Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 5, pp 494–498 | Cite as

Role of Matrix Metalloproteinases 2 and 9 in Determination of Invasive Potential of Pancreatic Tumors

  • L. E. Gurevich


Our findings indicate that expression of matrix metalloproteinase-2 is an important prognostic marker of invasive potential of pancreatic tumors. Expression of this marker in neuroendocrine tumors (particularly in gastrinomas) can be used as a differential diagnostic criterion characterizing more malignant phenotype of tumors with the presence of ductal component. On the contrary, weak expression matrix metalloproteinase-9 is characteristic of less invasive phenotype of tumor cells (neuroendocrine and solid pseudopapillary tumors, mucinous cystadenomas). Co-expression of matrix metalloproteinases 2 and 9 is an unfavorable prognostic sign.

metalloproteinases pancreatic tumors invasive properties cell-to-cell interactions extracellular matrix destruction 


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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • L. E. Gurevich
    • 1
    • 2
  1. 1.M. F. Vladimirskii Moscow Regional Research and Clinical InstituteMoscow
  2. 2.Russian Academy of Medical SciencesInstitute of Human MorphologyMoscow

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