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Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 5, pp 471–473 | Cite as

Anticoagulant Activity of Fucoidan from Brown Algae Fucus evanescens of the Okhotsk Sea

  • T. A. KuznetsovaEmail author
  • N. N. Besednova
  • A. N. Mamaev
  • A. P. Momot
  • N. M. Shevchenko
  • T. N. Zvyagintseva
Article

Abstract

In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.

anticoagulants fucoidans sulfated polysaccharides heparin 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • T. A. Kuznetsova
    • 1
    • 2
    Email author
  • N. N. Besednova
    • 1
    • 2
  • A. N. Mamaev
    • 1
    • 2
  • A. P. Momot
    • 1
    • 2
  • N. M. Shevchenko
    • 1
    • 2
  • T. N. Zvyagintseva
    • 1
    • 2
  1. 1.Siberian Division of the Russian Academy of Medical SciencesInstitute of Epidemiology and MicrobiologyVladivostok
  2. 2.Far-Eastern Division of the Russian Academy of SciencesPacific Ocean Institute of Bioorganic ChemistryVladivostok

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