Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 4, pp 325–327 | Cite as

Secretory Activity of Mast Cell during Stress: Effect of Prolyl-Glycyl-Proline and Semax

  • B. A. Umarova
  • G. N. Kopylova
  • E. A. Smirnova
  • A. A. Guseva
  • S. E. Zhuikova
Article

Abstract

Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.

stress mast cells proline-containing peptides 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • B. A. Umarova
    • 1
  • G. N. Kopylova
    • 1
  • E. A. Smirnova
    • 1
  • A. A. Guseva
    • 1
  • S. E. Zhuikova
    • 1
  1. 1.Department of Human and Animal Physiology, Biological FacultyM. V. Lomonosov Moscow State UniversityRussia

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