Neuroscience and Behavioral Physiology

, Volume 31, Issue 1, pp 71–74 | Cite as

The Effects of Prenatal Stress on Learning in Rats in a Morris Maze

  • A. A. Aleksandrov
  • O. N. Polyakova
  • A. S. Batuev
Article

Abstract

The offspring of female Wistar rats subjected to daily stress (they were placed in an unfamiliar social group for 1 h) during the last third of pregnancy were studied. The offspring of these females were tested for the ability to perform spatial orientation in a Morris water maze at the ages of two and four months. Prenatal stress had no effect on the ability of rats to learn in the Morris maze. However, two-month-old animals subjected to prenatal stress, unlike controls, demonstrated less flexibility in their behavioral strategy in solving the spatial orientation task. These animals were characterized by a clear tendency for their behavior to perseverate. By the age of four months, the differences between the control and prenatally stressed animals had disappeared.

prenatal stress social stress learning Morris water maze 

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REFERENCES

  1. 1.
    A. S. Batuev, E. P. Vinogradova, and O. N. Polyakova, “The effects of stress in pregnant rats on anxiety levels in offspring,” Zh. Vyssh. Nerv. Deyat., 46, 558–563 (1996).Google Scholar
  2. 2.
    E. P. Vinogradova, O. N. Polyakova, and A. S. Batuev, “The effects of prenatal ‘pain’ and ‘emotional’ stress on the characteristics of learning in rats,” Zh. Vyssh. Nerv. Deyat., 6, 1097–1103 (1996).Google Scholar
  3. 3.
    J. M. Deminiere, P. V. Piazza, G. Guegan, N. Abrous, et al., “Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers,” Brain Res., 586, 135–139 (1992).Google Scholar
  4. 4.
    E. Fride, Y. Dan, J. Feldon, G. Halevy, et al., “Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats,” Physiol. Behav., 37, 681–687 (1986).Google Scholar
  5. 5.
    M. Gallagher, R. Burwell, and M. Burchinal, “Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze,” Behav. Neurosci., 107, 618–626 (1993).Google Scholar
  6. 6.
    P. J. Gutierrez and J. S. Meyer, “Effect of stress during development on spatial learning in rats,” Soc. Neurosci. Abstr., 15, 94 (1989).Google Scholar
  7. 7.
    W. F. McDaniel, D. M. Compton, and S. R. Smith, “Spatial learning following posterior parietal or hippocampal lesions,” NeuroReport, 5, 1713–1717 (1994).Google Scholar
  8. 8.
    R. G. M. Morris, P. Garrud, J. N. P. Rawlins, and J. O'Keefe, “Place navigation impaired in rats with hippocampal lesion,” Nature, 297, 681–683 (1982).Google Scholar
  9. 9.
    T. Poltyrev, G. I. Keshet, G. Kay, and M. Weinstock, “Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats,” Dev. Psychobiol., 29, 453–462 (1996).Google Scholar
  10. 10.
    T. Szuran, E. Zimmerman, V. Pliska, H. P. Pfister, and H. Welzl, “Prenatal stress effects on exploratory activity and stress-induced analgesia in rats,” Dev. Psychobiol., 24, 361–372 (1991).Google Scholar
  11. 11.
    T. Szuran, E. Zimmerman, and H. Welzl, “Water maze performance and hippocampal weight of prenatally stressed rats,” Behav. Brain Res., 65, 153–155 (1994).Google Scholar

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • A. A. Aleksandrov
    • 1
  • O. N. Polyakova
    • 1
  • A. S. Batuev
    • 1
  1. 1.Department of Higher Nervous Activity and PsychophysiologySt. Petersburg State UniversitySt. PetersburgRussia

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